Document Detail

Effects of opium addiction on bleeding after coronary artery bypass graft surgery: report from Iran.
MedLine Citation:
PMID:  20859724     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Opium abuse is a major type of drug abuse in Iran. This study was designed to find the possible relation between opium addiction and excessive bleeding after coronary artery bypass graft (CABG) surgery.
METHODS: In a historical cohort study during a 1.5-year period, consecutive patients scheduled for elective CABG surgery were assigned to two group on the basis of having or not having the criteria for inhalational opium addiction. Before and after operations, the complete blood count, bleeding time, prothrombin time, partial thromboplastin time, and platelet count were checked for all patients. The volumes of infused red blood cells during and after the operation were recorded. After operations, the volumes of bleeding through the patients' chest tubes were recorded. The recorded data were analyzed using SPSS software version 11.5. Independent t, chi-square and repeated measure tests were used; and P < 0.05 was considered statistically significant.
RESULTS: In total, 84 nonaddicted patients were assigned in group 1, and 110 patients who fulfilled the addiction criteria were assigned in group 2. Total bleeding from the three chest tubes was significantly different between the two groups (P = 0.001). The mean hemoglobin level, prothrombin time, partial thromboplastin time, and platelet counts before and after the operations were similar in the two groups. Opium-addicted patients received more packed red blood cells during and after the operations.
CONCLUSION: Inhalational opium addiction might lead to more hemorrhage after CABG surgery. It is recommended that cardiac surgeons consider these patients at high risk for major complications after surgery.
Mohammad Hassan Nemati; Behrooz Astaneh; Gholamreza Safaee Ardekani
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Publication Detail:
Type:  Journal Article     Date:  2010-09-22
Journal Detail:
Title:  General thoracic and cardiovascular surgery     Volume:  58     ISSN:  1863-6713     ISO Abbreviation:  Gen Thorac Cardiovasc Surg     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101303952     Medline TA:  Gen Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  456-60     Citation Subset:  IM    
Cardiac Surgery Department, Faghihi Hospital, Shiraz University of Medical Sciences, Zand Street, Shiraz, Iran.
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MeSH Terms
Coronary Artery Bypass / adverse effects*
Middle Aged
Opioid-Related Disorders / complications*
Opium / adverse effects*
Postoperative Hemorrhage / etiology*
Reg. No./Substance:

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