| Effects of opioid blockade on nociceptive flexion reflex thresholds and nociceptive responding in hypertensive and normotensive individuals. | |
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MedLine Citation:
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PMID: 18436318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension and risk for hypertension have been associated with reduced pain sensitivity. It has been hypothesised that endogenous opioids contribute to this hypertensive hypoalgesia. The nociceptive flexion reflex can be used as a tool to investigate modulation of nociceptive transmission at spinal level. The current study employed a double-blind placebo-controlled design to compare the effects of naltrexone, an opioid antagonist, and placebo on nociceptive flexion reflex thresholds and nociceptive responding in unmedicated patients with essential hypertension and normotensive individuals. Neither nociceptive flexion reflex thresholds nor nociceptive responding differed between hypertensives and normotensives during placebo or naltrexone. These data provide no support for the hypothesis that essential hypertension is characterised by higher levels of endogenous opioids in the central nervous system and reveal no association between blood pressure status and nociceptive flexion reflex responses. |
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Authors:
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Louisa Edwards; Christopher Ring; Christopher R France; David McIntyre; Una Martin |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2008-03-15 |
Journal Detail:
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Title: International journal of psychophysiology : official journal of the International Organization of Psychophysiology Volume: 69 ISSN: 0167-8760 ISO Abbreviation: Int J Psychophysiol Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-06-30 Completed Date: 2008-09-30 Revised Date: 2011-09-12 |
Medline Journal Info:
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Nlm Unique ID: 8406214 Medline TA: Int J Psychophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 96-100 Citation Subset: IM |
Affiliation:
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International Centre for Health and Exercise Research, University of Birmingham, Birmingham, B15 2TT, UK. l.edwards@bham.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Double-Blind Method Female Humans Hypertension / complications*, metabolism Male Middle Aged Naltrexone / pharmacology* Narcotic Antagonists / pharmacology* Opioid Peptides / metabolism Pain Measurement Pain Threshold / drug effects* Reference Values Reflex / drug effects Somatosensory Disorders / complications*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL064794-04/HL/NHLBI NIH HHS; R01 HL64794/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 0/Opioid Peptides; 16590-41-3/Naltrexone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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