| Effects on open-field behavior of diazepam and buspirone alone and in combination with chronic caffeine. | |
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MedLine Citation:
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PMID: 8412479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of diazepam (1, 2 mg/kg) and buspirone (1.25, 2.5 mg/kg) on locomotor and rearing activity were observed in rats tested in an open field. Both doses of each drug reduced ambulation. However, for buspirone, this effect was confined to females. Walking and rearing was reduced by the higher dose of diazepam and rearing by both doses of buspirone. In rats that had ingested approximately 26 mg/kg/day of chronic caffeine for seven days prior to and immediately before testing, all effects of diazepam observed earlier failed to achieve significance except for ambulation. However, all earlier buspirone effects (including female-only decreased ambulation) were unaffected by the caffeine treatment. It was concluded that buspirone may be preferable to diazepam as an anxiolytic when in the presence of regular caffeine ingestion. |
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Authors:
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R N Hughes |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Life sciences Volume: 53 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-10-28 Completed Date: 1993-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1217-25 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Canterbury, Christchurch, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects* Buspirone / pharmacology* Caffeine / pharmacology* Diazepam / pharmacology* Drug Interactions Female Male Rats Rats, Wistar Sex Factors |
| Chemical | |
Reg. No./Substance:
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36505-84-7/Buspirone; 439-14-5/Diazepam; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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