Document Detail

Effects on open-field behavior of diazepam and buspirone alone and in combination with chronic caffeine.
MedLine Citation:
PMID:  8412479     Owner:  NLM     Status:  MEDLINE    
Effects of diazepam (1, 2 mg/kg) and buspirone (1.25, 2.5 mg/kg) on locomotor and rearing activity were observed in rats tested in an open field. Both doses of each drug reduced ambulation. However, for buspirone, this effect was confined to females. Walking and rearing was reduced by the higher dose of diazepam and rearing by both doses of buspirone. In rats that had ingested approximately 26 mg/kg/day of chronic caffeine for seven days prior to and immediately before testing, all effects of diazepam observed earlier failed to achieve significance except for ambulation. However, all earlier buspirone effects (including female-only decreased ambulation) were unaffected by the caffeine treatment. It was concluded that buspirone may be preferable to diazepam as an anxiolytic when in the presence of regular caffeine ingestion.
R N Hughes
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  53     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-28     Completed Date:  1993-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1217-25     Citation Subset:  IM    
Department of Psychology, University of Canterbury, Christchurch, New Zealand.
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MeSH Terms
Behavior, Animal / drug effects*
Buspirone / pharmacology*
Caffeine / pharmacology*
Diazepam / pharmacology*
Drug Interactions
Rats, Wistar
Sex Factors
Reg. No./Substance:
36505-84-7/Buspirone; 439-14-5/Diazepam; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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