Document Detail

Effects of an onion-olive oil maceration product containing essential ingredients of the Mediterranean diet on blood pressure and blood fluidity.
MedLine Citation:
PMID:  11258039     Owner:  NLM     Status:  MEDLINE    
Twenty-four patients with arterial hypertension (WHO class I) received either 4 capsules of an onion-olive oil maceration product, containing essential ingredients of the Mediterranean diet, or placebo daily over a period of one week. In order to investigate the acute effect on arterial blood pressure, measurements were performed before and 5 h after the administration of the first dose of 4 capsules verum or placebo, respectively. For the evaluation of the long term effect further blood pressure measurements were performed after one week's treatment with a daily dose of 4 capsules. After a wash-out phase of 2 weeks followed by a crossover, the second study phase, which was identical in design, was carried out. In addition patients were instructed to measure their blood pressure 4 times daily at home for the whole study period. Haemorheological parameters (platelet aggregation, erythrocyte aggregation, plasma viscosity and haematocrit) were also determined at the measuring points mentioned above. The onion-olive oil maceration product led to a significant decrease in systolic blood pressure. There was also a trend towards a decrease in diastolic blood pressure. The improved blood fluidity observed resulted from a decrease in haematocrit. All effects could be shown immediately and after one week's administration.
B Mayer; U Kalus; A Grigorov; G Pindur; F Jung; H Radtke; K Bachmann; C Mrowietz; J Koscielny; E Wenzel; H Kiesewetter
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  51     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  104-11     Citation Subset:  IM    
Medizinische Fakultät, Humboldt Universität zu Berlin, Institut für Transfusionsmedizin, Universitätsklinikum Charité, Berlin, Germany.
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MeSH Terms
Blood / drug effects
Blood Pressure / drug effects*
Double-Blind Method
Hypertension / drug therapy*,  physiopathology
Mediterranean Region
Onions / chemistry*
Plant Oils / adverse effects,  chemistry,  therapeutic use*
Reg. No./Substance:
0/Plant Oils; 8001-25-0/olive oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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