Document Detail

Effects of one-year cadmium exposure on livers and kidneys and their relation to glutathione levels.
MedLine Citation:
PMID:  7670849     Owner:  NLM     Status:  MEDLINE    
To study the effects of a long-term cadmium exposure on livers and kidneys, rats were administered cadmium chloride (0.228 mg Cd/kg, 3 days/week ip), for one year. Significant accumulation of cadmium was observed in livers (183 +/- 40 micrograms/g liver) and kidneys (92 +/- 17 micrograms/g kidney). Serum urea nitrogen and creatinine levels were significantly elevated in the cadmium-treated rats, while liver function tests were minimally affected. Histological observations showed interstitial fibrosis with minimal cell necrosis and inflammatory cell infiltration in livers, and apparent degeneration of proximal tubules and infiltration of inflammatory cells in parenchyma of kidneys. Lipid peroxidation in livers and kidneys, as assessed by thiobarbituric acid reactive substances, revealed no differences between the cadmium-treated rats and the controls. Glutathione contents were significantly increased in the cadmium treated rats both in livers (p < 0.001), and in kidneys (p < 0.001) compared with the controls. Increased glutathione levels in livers may contribute, in part, to the prevention of serious hepatotoxicity during chronic cadmium exposure, while nephrotoxicity due to cadmium may not be prevented by glutathione.
T Kamiyama; H Miyakawa; J P Li; T Akiba; J H Liu; J Liu; F Marumo; C Sato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  88     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-18     Completed Date:  1995-10-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  177-86     Citation Subset:  IM    
Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Cadmium / pharmacokinetics,  toxicity*
Glutathione / metabolism*
Kidney / drug effects*,  metabolism,  pathology
Liver / drug effects*,  metabolism,  pathology
Rats, Sprague-Dawley
Reg. No./Substance:
70-18-8/Glutathione; 7440-43-9/Cadmium

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