| Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition1,2. | |
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MedLine Citation:
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PMID: 21159785 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: In addition to the metabolic and cardiovascular benefits of omega-3 (n-3) fatty acids, several studies have suggested an added weight loss-enhancing benefit to this supplement. OBJECTIVE: The objective was to assess whether supplemental omega-3 fatty acids in conjunction with diet and exercise augment weight loss over a 6-mo period. DESIGN: In a single-institution, placebo-controlled, randomized clinical trial, 128 individuals with a body mass index (in kg/m(2)) between 26 and 40 were assigned to receive 5 omega-3 [3.0 g eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) at a 5:1 ratio (EPA:DHA)] or placebo capsules daily in conjunction with lifestyle modification. The primary endpoint was weight loss; secondary endpoints included metabolic and psychometric variables. Analyses were by intention-to-treat. RESULTS: Overweight and obese individuals were assigned to the omega-3 arm (n = 64) or to the placebo arm (n = 64). Subjects in both arms received dietary and exercise counseling. Eighty-one individuals completed the 24-wk study, and the dropout rate was 27%. Subjects in both arms lost an average of >5% of their body weight. No significant differences in weight loss were observed between the omega-3 (-5.2 kg; 95% CI: -6.0, -4.4 kg) and placebo (-5.8 kg; 95% CI: -6.7, -5.1 kg) arms. The absolute mean (±SEM) change difference was 0.61 ± 0.58 kg (P = 0.29). In addition, no significant differences in the other factors assessed were observed. CONCLUSION: Omega-3 fatty acids were not effective as an adjunct for weight loss in this otherwise healthy, overweight population. |
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Authors:
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Laura F Defina; Lucille G Marcoux; Susan M Devers; Joseph P Cleaver; Benjamin L Willis |
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Publication Detail:
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Type: Journal Article Date: 2010-12-15 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 93 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 455-62 Citation Subset: AIM; IM |
Affiliation:
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From The Cooper Institute, Dallas, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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