| Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 23017309 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: Polycystic ovary syndrome (PCOS) is a common female endocrine disorder associated with several risk factors of type 2 diabetes and cardiovascular diseases. The objectives of this study were to investigate the effects of omega-3 fatty acids on serum adiponectin levels and some metabolic risk factors in PCOS patients. Methods: This double-blind randomized controlled clinical trial was conducted on 64 overweight or obese PCOS patients; aged 20-35 years. Subjects in omega-3 fatty acids (n=32) and placebo (n=32) groups were given 4 omega- 3 fatty acids capsules (each one contained 180 mg eicosapentaenoic acid and 120 mg docosahexanoic acid) or placebo daily for 8 weeks. Fasting blood samples, anthropometric measurements and 3-day, 24-hour dietary recalls were collected at the baseline and at the end of the trial. Results: The study was completed by 61 subjects. Omega-3 fatty acids significantly increased serum levels of adiponectin (p=0.003) and decreased glucose (p<0.001), insulin (p=0.002), homeostatic model assessment for insulin resistance (p<0.001), total cholesterol (p=0.002) and low-density lipoprotein cholesterol (p=0.003) compared with placebo. Serum levels of triglyceride significantly decreased (p=0.024) and high-density lipoprotein cholesterol increased (p=0.018) in the omega-3 fatty acids group, in comparison with baseline values. No significant changes were shown in serum high sensitive C-reactive protein (hs-CRP) levels in both groups. Conclusion: Omega-3 fatty acids had some beneficial effects on serum adiponectin levels, insulin resistance and lipid profile in PCOS patients and may contribute to the improvement of metabolic complications in these patients. |
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Authors:
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Elahe Mohammadi; Maryam Rafraf; Laya Farzadi; Mohammad Asghari-Jafarabadi; Siamak Sabour |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asia Pacific journal of clinical nutrition Volume: 21 ISSN: 0964-7058 ISO Abbreviation: Asia Pac J Clin Nutr Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440304 Medline TA: Asia Pac J Clin Nutr Country: Australia |
Other Details:
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Languages: eng Pagination: 511-8 Citation Subset: IM |
Affiliation:
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Nutrition Research Center, Department of Nutrition in Community, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. rafrafm@tbzmed.ac.ir. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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