Document Detail


Effects of omega-3 fatty acids on coronary restenosis, intima-media thickness, and exercise tolerance: a systematic review.
MedLine Citation:
PMID:  16084516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Greater omega-3 fatty acid consumption is associated with reduced cardiovascular disease risk. Though the mechanisms of their effect are unclear, they may involve lesion formation and heart function. We conducted a systematic review of the clinical literature on the effect of omega-3 fatty acids on measures of vascular structure and function. We included studies that assessed fish and plant sources of omega-3 fatty acids on coronary artery restenosis after angioplasty, carotid IMT, and exercise capacity. Compared to placebo, the summary risk ratio of coronary artery restenosis with fish oil is 0.87 (95% CI 0.73, 1.05) across 12 randomized controlled trials. Two prospective studies reported increased carotid IMT, whereas two cross-sectional studies reported a reduction of IMT, with fish, fish oil or ALA consumption. Three randomized trials and three uncontrolled studies reported small non-significant improvements in exercise capacity with fish oil. Overall, little or no effect of fish oil was found for a variety of markers of cardiovascular disease risk. There are insufficient studies to draw conclusions about the effect of ALA. The dearth of long term data on fish consumption or omega-3 fatty acid supplementation on measures of cardiovascular disease risk severely limits our ability to draw definitive conclusions at this time.
Authors:
Ethan M Balk; Alice H Lichtenstein; Mei Chung; Bruce Kupelnick; Priscilla Chew; Joseph Lau
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2005-08-09
Journal Detail:
Title:  Atherosclerosis     Volume:  184     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  237-46     Citation Subset:  IM    
Affiliation:
Tufts-New England Medical Center Evidence-based Practice Center, Institute for Clinical Research and Health Policy Studies, 750 Washington Street, NEMC 63, Boston, MA 02111, USA. ebalk@tufts-nemc.org
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MeSH Terms
Descriptor/Qualifier:
Carotid Arteries / ultrasonography
Coronary Restenosis / physiopathology,  prevention & control*,  ultrasonography
Exercise Test
Exercise Tolerance / drug effects,  physiology*
Fatty Acids, Omega-3 / therapeutic use*
Humans
Treatment Outcome
Tunica Intima / drug effects,  ultrasonography*
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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