| Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial. | |
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MedLine Citation:
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PMID: 17662577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prepulse inhibition (PPI), whereby the startle eyeblink response is inhibited by a relatively weak non-startling stimulus preceding the powerful startle eliciting stimulus, is a measure of sensorimotor gating and has been shown to be deficient in schizophrenia patients. There is considerable interest in whether conventional and/or atypical antipsychotic medications can "normalize" PPI deficits in schizophrenia patients. 51 schizophrenia patients participated in a randomized, double-blind controlled trial on the effects of three commonly-prescribed antipsychotic medications (risperidone, olanzapine, or haloperidol) on PPI, startle habituation, and startle reactivity. Patients were tested at baseline, Week 4 and Week 8. Mixed model regression analyses revealed that olanzapine significantly improved PPI from Week 4 to Week 8, and that at Week 8 patients receiving olanzapine produced significantly greater PPI than those receiving risperidone, but not haloperidol. There were no effects of medication on startle habituation or startle reactivity. These results support the conclusion that olanzapine effectively increased PPI in schizophrenia patients, but that risperidone and haloperidol had no such effects. The results are discussed in terms of animal models, neural substrates, and treatment implications. |
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Authors:
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Jonathan K Wynn; Michael F Green; Joyce Sprock; Gregory A Light; Clifford Widmark; Christopher Reist; Stephen Erhart; Stephen R Marder; Jim Mintz; David L Braff |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-07-26 |
Journal Detail:
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Title: Schizophrenia research Volume: 95 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-03 Completed Date: 2007-10-24 Revised Date: 2011-08-18 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 134-42 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. jkwynn@ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Antipsychotic Agents / therapeutic use* Benzodiazepines / pharmacology, therapeutic use Double-Blind Method Electromyography Female Habituation, Psychophysiologic / drug effects* Haloperidol / pharmacology, therapeutic use Humans Male Middle Aged Psychotic Disorders / drug therapy, psychology Risperidone / pharmacology, therapeutic use Schizophrenia / drug therapy* Schizophrenic Psychology Startle Reaction / drug effects* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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MH-042228/MH/NIMH NIH HHS; R01 MH042228-18/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 52-86-8/Haloperidol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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