Document Detail

Effects of olanzapine and other antipsychotic agents on responding maintained by a conflict schedule.
MedLine Citation:
PMID:  11224268     Owner:  NLM     Status:  Publisher    
The effects of the "atypical" antipsychotic olanzapine and several other antipsychotics were examined using a conflict schedule. Rats were trained to respond for food on a three-component schedule, comprising variable-interval 30s (food, VI30) and fixed-ratio 10s (food + shock, FR10) components separated by time-out (TO). Olanzapine (0.3125-1.25mg/kg), clozapine (1.25-5mg/kg) and chlordiazepoxide (2.5-5mg/kg) decreased or had no effect on VI30 responding, whereas responding in the FR10 component increased. Chlordiazepoxide (5mg/kg) also increased TO responding. The antipsychotic agents haloperidol (0.125 and 0.25mg/kg), trifluoperazine (0.0625-0.25mg/kg), remoxipride (1.25-5mg/kg) and risperidone (0.0625-0.5mg/kg) decreased V130 responding and either had no effect, or decreased TO and FR10 rates. The anticholinergic agent scopolamine (0.03125-0.25mg/kg) decreased VI30 responding. The 5-HT(2) antagonist ritanserin (2.5 and 5mg/kg) and the anticholinergic agent trihexyphenidyl (2.5 and 5mg/kg) had no effect on responding. Flumezanil (10mg/kg) reduced the anticonflict effect of chlordiazepoxide but not olanzapine. These results further emphasize the unusual profile of olanzapine.
N.A. Moore; G. Rees; G. Sanger; N.C. Tye
Related Documents :
8919008 - The hippocampus and reward: effects of hippocampal lesions on progressive-ratio respond...
238028 - Rate-dependent effects of drugs. ii. effects of some major tranquilizers on multiple fi...
5722418 - Summation of response rates to discriminative stimuli associated with qualitatively dif...
1774538 - An economic analysis of "demand" for food in baboons.
16053068 - Organochlorine contaminants in human adipose tissues from china: mass balance approach ...
11081418 - Effect of different types of litter material for rearing broilers.
Publication Detail:
Journal Detail:
Title:  Behavioural pharmacology     Volume:  5     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  1994 Apr 
Date Detail:
Created Date:  2001-Feb-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  196-202     Citation Subset:  -    
Lilly Research Centre, Eli Lilly & Co., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Opioid pharmacology of the antinociceptive effects of loperamide in mice.
Next Document:  Catalase inhibition attenuates the acquisition of ethanol and saccharin-quinine consumption in labor...