Document Detail

Effects of oestrogen and exercise on caspase-3 activity in primary and secondary lymphoid compartments in ovariectomized mice.
MedLine Citation:
PMID:  12392497     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The results suggest that oestrogen and treadmill exercise are associated with greater apoptosis, as measured by caspase-3 activity, in the thymus but not in the spleen or lymph nodes. Clinical studies will be necessary to determine if women who take oestrogen have higher rates of apoptosis in primary lymphoid tissues and the significance of thymocyte apoptosis for maintenance of cellular immune function during the post-menopausal years.
H Patel; L Hoffman-Goetz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  176     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-23     Completed Date:  2003-01-31     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-84     Citation Subset:  IM    
Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada.
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MeSH Terms
Apoptosis / drug effects,  immunology
Body Weight / immunology
Caspase 3
Caspases / metabolism*
Enzyme-Linked Immunosorbent Assay / methods
Estradiol / pharmacology
Estrogens / blood,  immunology*
Lymph Nodes / drug effects,  enzymology,  immunology
Lymphocytes / drug effects*,  enzymology,  immunology
Mice, Inbred Strains
Organ Size / immunology
Physical Conditioning, Animal / physiology*
Radioimmunoassay / methods
Spleen / drug effects,  enzymology,  immunology
Thymus Gland / drug effects,  enzymology,  immunology
Reg. No./Substance:
0/Estrogens; 50-28-2/Estradiol; EC 3.4.22.-/Casp3 protein, mouse; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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