Document Detail

Effects of ocular decongestants.
MedLine Citation:
PMID:  7378008     Owner:  NLM     Status:  MEDLINE    
Eight widely used commercially available ocular decongestants were compared on the basis of vasoconstrictive effectiveness. The ability of these preparations to counteract histamine-induced erythema and to block its recurrence when rechallenged after one hour was evaluated in six human subjects in seven sessions. All vasoconstrictors tested were effective. No preparation was statistically different from 0.02% naphazoline hydrochloride in vasoconstrictive effect. In fact, this intermediate concentration of naphazoline (0.02%) was found to be significantly better that the other nonprescription decongestant preparations tested as a group and not significantly different from a group of higher concentrations of naphazoline.
M B Abelson; G K Yamamoto; M R Allansmith
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  98     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-07-12     Completed Date:  1980-07-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  856-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antipyrine / pharmacology
Cornea / blood supply*
Double-Blind Method
Imidazoles / pharmacology
Naphazoline / pharmacology
Nonprescription Drugs
Phenylephrine / pharmacology
Tetrahydronaphthalenes / pharmacology
Vasoconstrictor Agents / administration & dosage,  pharmacology*
Vasodilation / drug effects*
Reg. No./Substance:
0/Imidazoles; 0/Nonprescription Drugs; 0/Tetrahydronaphthalenes; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine; 60-80-0/Antipyrine; 835-31-4/Naphazoline; 84-22-0/tetrahydrozoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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