| Effects of octreotide on lower esophageal sphincter in patients with cirrhosis and portal hypertension. | |
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MedLine Citation:
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PMID: 9690396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of octreotide infusion on the contractile activity of the esophageal body and lower esophageal sphincter in cirrhotic patients with esophageal varices. Esophageal manometry was performed in 36 alcoholic cirrhotic patients. They were randomly allocated to three groups and received the following treatments blindly for 90 min: an initial 100-microg intravenous bolus followed by a continuous 25 microg/hr octreotide infusion (group I, N= 13), a continuous 25 micro/hr octreotide infusion without an initial bolus (group II, N=13), and a continuous placebo infusion (group III, N=10). Before drug infusion, mean lower esophageal sphincter pressure and mean esophageal body contraction pressure and duration were similar in the three groups. Compared to the placebo group, lower esophageal sphincter pressure increased significantly in groups I and II, 30 min (30%, 22%, 3% respectively; P= 0.006), 60 min (44%, 35%, 0.6%; P=0.0002), and 90 min (67%, 41%, 2.5%; P=0.0001) after octreotide infusion, as did esophageal body contraction pressure and duration. We conclude that octreotide has a potent effect on LES tone in cirrhotic patients. |
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Authors:
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T Barrioz; C Borderie; P Strock; P Ingrand; E Fort; C Silvain; M Beauchant |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 43 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-08-19 Completed Date: 1998-08-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1566-71 Citation Subset: AIM; IM |
Affiliation:
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Service d'Hépato-gastroentérologie, Centre Hospitalier Universitaire, Poitiers, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Esophageal and Gastric Varices / physiopathology Esophagogastric Junction / drug effects*, physiopathology Esophagus / drug effects*, physiopathology Female Hormones / pharmacology* Humans Hypertension, Portal / physiopathology* Infusions, Intravenous Liver Cirrhosis, Alcoholic / physiopathology* Male Manometry Middle Aged Muscle Contraction / drug effects, physiology Muscle, Smooth / drug effects, physiopathology Octreotide / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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