Document Detail

Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men.
MedLine Citation:
PMID:  15551391     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Little is known about the effects of organic solvents on male reproductive health. To assess fertility and reproductive endocrine function in solvent-exposed men, we investigated time-to-pregnancy using a retrospective cohort design and cross-sectionally measured reproductive hormone concentrations in painters and millwrights compared to a reference group of carpenters. METHODS: Detailed occupational, exposure, medical, and time-to-pregnancy histories were obtained by telephone interview. Plasma luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. Exposure indices, which summarized working life exposure to total solvents, chlorinated solvents, aromatic solvents, and thinners, degreasers, varnishes, and adhesives as a category were calculated from exposure histories. RESULTS: FSH concentrations increased significantly with increasing exposure indices for all solvents and for chlorinated solvents. There were no significant associations of solvent exposure indices with LH or testosterone levels. LH, FSH, and testosterone concentrations also did not differ by job title. Using Cox regression, time-to-pregnancy was non-significantly longer in the painters and millwrights than the carpenters. There was no significant association between time-to-pregnancy and any of the solvent exposure indices; however, it should be noted that some of the pregnancies occurred more than 20 years previously, potentially reducing the reliability of the retrospectively collected pregnancy and exposure data. CONCLUSIONS: The significant associations between FSH levels and solvent exposure indices suggest the potential for adverse effects of solvent exposures on reproductive function in men.
Ulrike Luderer; Abigail Bushley; Bert D Stover; William J Bremner; Elaine M Faustman; Timothy K Takaro; Harvey Checkoway; Carl Andrew Brodkin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  46     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-24     Completed Date:  2005-03-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-26     Citation Subset:  IM    
Division of Occupational and Environmental Medicine, Department of Medicine, University of California, Irvine, California 92617, USA.
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MeSH Terms
Age Distribution
California / epidemiology
Chemical Industry
Cohort Studies
Fertility / physiology
Follow-Up Studies
Gonadal Hormones / analysis,  metabolism*
Gonadotropins / analysis,  metabolism
Infertility, Female / chemically induced*,  epidemiology
Infertility, Male / chemically induced*,  epidemiology
Linear Models
Middle Aged
Occupational Exposure / adverse effects*
Pregnancy / statistics & numerical data*
Risk Assessment
Solvents / adverse effects,  chemistry*
Testosterone / analysis,  metabolism
Grant Support
Reg. No./Substance:
0/Gonadal Hormones; 0/Gonadotropins; 0/Solvents; 58-22-0/Testosterone

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