Document Detail

Effects of occupational lead exposure on motor and somatosensory evoked potentials.
MedLine Citation:
PMID:  7854606     Owner:  NLM     Status:  MEDLINE    
In order to objectivate the effects of inorganic lead compounds on the nervous system, 17 men occupationally exposed have been recorded for Motor Electric Potentials (MEPs) of the abductor policis brevis muscles with transcranial, cervical root and peripheral electrical stimulations, for Somatosensory Evoked Potentials (SEPs) of median and tibial posterior nerves, and for Electromyography (EMG). Considering each subject, 16 out of the 17 lead exposed ones exhibited electrophysiological abnormalities, occurring at both peripheral and central levels for the somatosensory as well as for the motor systems. As compared to a normal control group, the lead exposed one showed decreased sensory and motor peripheral conduction velocities, increased motor central conduction time, and delayed cortical P22 SEPs component that could be interpreted as a sensory-motor cortical dysfunction. The respective contributions of MEPs and SEPs are compared to clinical, biological and EMG examinations in the evaluation of the neurotoxic effects of inorganic lead compounds.
F Lille; S Margules; E Fournier; S Dally; R Garnier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  15     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  679-83     Citation Subset:  IM    
Laboratoire de Physiologie--CHU Pitié-Salpétrière, Paris, France.
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MeSH Terms
Age Factors
Electric Stimulation
Erythrocytes / chemistry
Evoked Potentials, Somatosensory / drug effects*
Lead / adverse effects*,  blood
Middle Aged
Muscles / drug effects*,  physiology
Occupational Exposure / adverse effects*
Protoporphyrins / blood
Reg. No./Substance:
0/Protoporphyrins; 15442-64-5/zinc protoporphyrin; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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