| Effects of occlusion on the skin of atopic dermatitis patients. | |
| | |
MedLine Citation:
|
PMID: 20920411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Atopic dermatitis (AD) may be exacerbated by occlusion from items such as occlusive gloves or textiles, especially if the occlusion is removed suddenly, creating a steep humidity gradient. Most previous studies of occlusion have focused on normal skin. Occlusion has been shown to be beneficial in psoriatic skin, but many atopic patients complain of increased inflammation after occlusion. OBJECTIVE: To evaluate the response of noninflamed AD skin to occlusion. METHODS: Six patients with AD were patch-tested with occlusive polyethylene wrap and sodium lauryl sulfate (SLS) in standard Finn Chambers taped to noninflamed skin of the back. Cytokine and chemokine messenger ribonucleic acid (mRNA) for interleukin-8 (IL-8), interleukin-1 alpha (IL-1α), and interleukin-1 receptor antagonist (IL-1RA), as well as the 18S rRNA housekeeping gene, was obtained via tape-stripping the skin and measured using quantitative real-time polymerase chain reaction. We also measured transepidermal water loss after removal of occlusion. RESULTS: Polyethylene occlusion alone with abrupt removal induced IL-8 and IL-1α levels similar to or exceeding that of SLS. IL-1RA was up-regulated by SLS and occlusion, with SLS showing a stronger response. CONCLUSION: Removal of occlusion with polyethylene film up-regulates the inflammatory cytokines IL-8, IL-1α, and IL-1RA in patients with AD. This may explain the worsening of AD with the use of occlusive gloves, athletic equipment, and fabrics. |
| | |
Authors:
|
Kristen Kobaly; Ally-Khan Somani; Thomas McCormick; Susan T Nedorost |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group Volume: 21 ISSN: 1710-3568 ISO Abbreviation: Dermatitis Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-05 Completed Date: 2011-01-31 Revised Date: 2011-05-22 |
Medline Journal Info:
|
Nlm Unique ID: 101207335 Medline TA: Dermatitis Country: Canada |
Other Details:
|
Languages: eng Pagination: 255-61 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cytokines
/
biosynthesis,
genetics Dermatitis, Atopic / immunology* Humans Occlusive Dressings / adverse effects Polyethylene / adverse effects* RNA / analysis Skin / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 63231-63-0/RNA; 9002-88-4/Polyethylene |
| Comments/Corrections | |
Erratum In:
|
Dermatitis. 2011 Feb;22(1):62 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Patch testing in atopic dermatitis.
Next Document: Irritant and sensitizing potential of eight surfactants commonly used in skin cleansers: an evaluati...