| Effects of oat bran, processed to different molecular weights of beta-glucan, on plasma lipids and caecal formation of SCFA in mice. | |
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MedLine Citation:
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PMID: 20334710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, we evaluated the cholesterol-lowering effects of different oat bran (OB) preparations, differing regarding their peak molecular weight (MWp) of beta-glucans (2348, 1311, 241, 56, 21 or < 10 kDa), in C57BL/6NCrl mice. The diets were designed to be atherogenic (0.8 % cholesterol and 0.1 % cholic acid), and they reflected the Western diet pattern (41 % energy fat). All OB preparations that were investigated significantly reduced plasma cholesterol when compared with a cellulose-containing control diet, regardless of the molecular weight of beta-glucan. Moreover, the difference in viscous properties between the processed OB (from 0.11 to 17.7 l/g) did not appear to play a major role in the cholesterol-lowering properties. In addition, there was no correlation between the molecular weight of beta-glucan and the amount of propionic acid formed in caecum. Interestingly, however, there was a significant correlation between the ratio of (propionic acid+butyric acid)/acetic acid and the MWp of beta-glucans: the ratio increased with increasing molecular weight. The results of the present study suggest that the molecular weights and viscous properties of beta-glucan in oat products may not be crucial parameters for their cholesterol-lowering effects. |
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Authors:
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Tina Immerstrand; Kristina E Andersson; Caroline Wange; Ana Rascon; Per Hellstrand; Margareta Nyman; Steve W Cui; Björn Bergenståhl; Christian Trägårdh; Rickard Oste |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-25 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-12 Revised Date: 2011-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 364-73 Citation Subset: IM |
Affiliation:
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Division of Applied Nutrition and Food Chemistry, Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden. tina.immerstrand@appliednutrition.lth.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / chemistry, pharmacology* Avena sativa* Cecum / metabolism* Cholesterol / blood* Dietary Fiber / administration & dosage Fatty Acids / metabolism* Female Mice Mice, Inbred C57BL Molecular Weight Plant Preparations / chemistry, pharmacology* Seeds Viscosity beta-Glucans / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Fatty Acids; 0/Plant Preparations; 0/beta-Glucans; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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