Document Detail

Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration.
MedLine Citation:
PMID:  8297914     Owner:  NLM     Status:  MEDLINE    
Oat bran concentrated with respect to both soluble and insoluble dietary fibre was fed to adult rats, and its effects on serum cholesterol and liver fat infiltration were studied. The feeds contained 15, 30 or 45 g beta-glucan/kg, except in control groups where the fibre of the feed was cellulose. Half the experimental groups received the feeds with an addition of 10 g cholesterol and 2 g cholic acid/kg in order to create an hypercholesterolaemic condition. In normocholesterolaemic rats the concentrated oat bran did not cause any significant changes in serum cholesterol concentrations, but reduced liver weight compared with control group rats fed on the cellulose-containing diet. In hypercholesterolaemic rats the concentrated oat bran reduced serum total cholesterol and increased high-density-lipoprotein cholesterol concentration. The effect was seen already at the 15 g/kg concentration of beta-glucan, the higher doses tested did not significantly improve the effect. Infiltration of fat into liver cells, especially in the periportal areas, was observed only in hypercholesterolaemic animals. The fat infiltration was accentuated in proportion to the amount of oat-bran concentrate fed.
Y Mälkki; R Törrönen; K Pelkonen; O Myllymäki; O Hänninen; K Syrjänen
Related Documents :
15508014 - Lupin kernel fibre-enriched foods beneficially modify serum lipids in men.
6092284 - Biogenic silica fibre promotes carcinogenesis in mouse skin.
14672874 - Whole cereal and legume seeds increase faecal short chain fatty acids compared to groun...
7784394 - Nutrient content of young cassava leaves and assessment of their acceptance as a green ...
18441084 - Effects of neonatal iron status, iron injections at birth, and weaning in young pigs fr...
25253084 - The physiology underlying roux-en-y gastric bypass - a status report.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  70     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-10     Completed Date:  1994-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  767-76     Citation Subset:  IM    
Technical Research Centre of Finland, Food Research Laboratory, Espoo.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cellulose / administration & dosage
Cholesterol / blood*
Dietary Fiber*
Fatty Liver / metabolism*,  pathology
Glucans / administration & dosage
Liver / metabolism*,  pathology
Reg. No./Substance:
0/Glucans; 57-88-5/Cholesterol; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ileal pH and apparent absorption of magnesium in rats fed on diets containing either lactose or lact...
Next Document:  Iron status in rats fed on diets containing marginal amounts of vitamin A.