Document Detail

Effects of nutritional support in patients with colorectal cancer during chemotherapy.
MedLine Citation:
PMID:  18982745     Owner:  NLM     Status:  MEDLINE    
Nutritional support, addressing the specific needs of this patient group, is required to help improve prognosis, and reduce the consequences of cancer-associated nutritional decline. Early intervention with nutritional supplementation has been shown to halt malnutrition, and may improve outcome in some patients. In our study we tried to assess the influence of nutritional support (counseling, oral liquids, megestrol acetate) on nutritional status and symptoms prevalence in patients with colorectal cancer during chemotherapy. Group I consisted of 215 (55%) patients with medium age 68 +/- 2.6 years who were monitored prospectively and were given nutritional support. Group II included 173 (45%) patients (medium age 67 +/- 2.9 years) without the proper nutritional counseling, in whom the data were collected retrospectively during a 6 years period of time. After evaluation Nottingham Screening Tool Score, Appetite Loss Scale and Karnofsky Performance Status) all patients in the group I received nutritional counseling, 153 of them (72%) were taking form of enteral food supplement and 103 (48%) patients were using megestrol acetate. Evaluating the initial risk measurements according to BMI, decrease in weight gain and NST, we did not find any significant difference between the two groups. After chemotherapy completion, patients in group I had a 15.3% drop of those who's BMI was < 20.65% patients increased their body weight, with an average weight gain of 1.5 kg (0.6-2.8 kg). Contrary, in group II we found increase in weight loss > or = 2 kg/month in 39% of patients. The appetite improvement was detected on Appetite Loss Scale from 3.1 (pre-chemotherapy) to 4.7 (post-chemotherapy) in group I, especially in those receiving megestrol acetate. In both groups Karnofsky Performance Status didn't change significantly reflecting the impact of the disease itself and chemotherapy procedures to the patient's condition. Nutritional counseling, supplemental feeding and pharmacological support do temporarily stop weight loss and improve appetite, social life and quality of life in those groups of patients. However, this improvement have no implications on patients KPS and course of their disease.
Renata Dobrila Dintinjana; Tina Guina; Zeljko Krznarić; Mladen Radić; Marijan Dintinjana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Collegium antropologicum     Volume:  32     ISSN:  0350-6134     ISO Abbreviation:  Coll Antropol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2008-12-18     Revised Date:  2009-02-04    
Medline Journal Info:
Nlm Unique ID:  8003354     Medline TA:  Coll Antropol     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  737-40     Citation Subset:  IM    
Gastroenterology Department, University Hospital Center "Rijeka", Rijeka, Croatia.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  therapeutic use
Body Mass Index
Camptothecin / administration & dosage,  analogs & derivatives
Colorectal Neoplasms / drug therapy*
Fluorouracil / administration & dosage
Leucovorin / administration & dosage
Nutritional Status
Nutritional Support*
Quality of Life
Retrospective Studies
Weight Loss
Reg. No./Substance:
0/IFL protocol; 51-21-8/Fluorouracil; 58-05-9/Leucovorin; 7689-03-4/Camptothecin

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