| Effects of nutritional supplementation on the appetite and energy intake responses to IV cholecystokinin in older adults. | |
| | |
MedLine Citation:
|
PMID: 20800632 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Human aging is associated with a reduction in appetite and food intake. Increased activity of the satiety hormone, cholecystokinin (CCK), may be partly responsible. This study aimed to determine whether an increase in fat and energy intake modifies the suppressive effects of CCK-8 on appetite and energy intake. Fourteen healthy older adults completed three separate dietary periods, a 14-day and a 7-day normal diet (ND; 8272 ± 480 kJ/day; 35% fat), and a 14-day high-fat diet (HFD; 11,642 ± 414 kJ/day; 43% fat), in randomised order. Immediately following each diet, subjects received, in single-blinded fashion, a 30-min intravenous infusion of either CCK-8 (1.5 ng/kg/min) (ND-CCK, HFD-CCK) or 0.9% saline (ND-SAL), the latter following only ND. Plasma CCK concentrations, appetite responses and energy intake at a buffet meal were determined. Energy intake at the buffet meal was higher on the ND-SAL study day (3349 ± 224 kJ), when compared with either ND-CCK (3023 ± 317 kJ) or HFD-CCK (2905 ± 316 kJ). The suppression of energy intake by CCK-8 infusion did not differ between the two diets. We conclude that suppression of energy intake by exogenous CCK-8 does not appear to be attenuated by incorporation of supplemental high-energy, high-fat drinks in the diet of healthy older adults. |
| | |
Authors:
|
Kamilia Tai; Christine Feinle-Bisset; Michael Horowitz; Judith M Wishart; Ian M Chapman |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-26 |
Journal Detail:
|
Title: Appetite Volume: 55 ISSN: 1095-8304 ISO Abbreviation: Appetite Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006808 Medline TA: Appetite Country: England |
Other Details:
|
Languages: eng Pagination: 473-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, South Australia, Australia. kamilia.tai@alumni.adelaide.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oligoarginine-linked polymers as a new class of penetration enhancers.
Next Document: Effects of PACAP and VIP on hyperglycemia-induced proliferation in murine microvascular endothelial ...