Document Detail

Effects of a nutritional intervention in obese postmenopausal women on atypical antipsychotics.
MedLine Citation:
PMID:  20605075     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the effects of a nutritional intervention on the body weight, body composition, blood glucose and lipid levels of obese postmenopausal women taking atypical antipsychotics in Greece.
STUDY DESIGN: In a case-control design, 25 obese postmenopausal women treated with antipsychotic medications and 28 obese healthy comparisons were followed for 3 months. A nutritional program was individually designed for each participant.
MAIN OUTCOME MEASURES: At baseline and at 3 months of the study, anthropometric, body composition, blood glucose and lipid measurements were performed.
RESULTS: Significant reductions in body weight, body mass index (BMI), fat and waist circumference were found both in the patients and their healthy comparisons from baseline to 3 months (P<0.05). Patients reduced significantly less their BMI (P=0.044) and body fat percentage compared to the healthy women (P=0.023). Waist circumference was significantly reduced in both subject groups, with no significant difference found between them (P=0.07). Glucose and lipid levels were not altered during the intervention in the patients' group, while significant changes were observed in the healthy women in total cholesterol (P=0.016), low density lipoprotein cholesterol (P=0.022) and triglycerides (P=0.042).
CONCLUSIONS: Obese postmenopausal women on atypical antipsychotic medication appear to respond favorably to a nutritional program. The improvements seen in BMI and body fat are attenuated in the patients compared to their healthy counterparts; moreover no change in lipid levels was found in the patients' group. These findings suggest that atypical antipsychotics may play an adverse role in fat loss and lipid metabolism in this population.
Maria Skouroliakou; Ifigenia Giannopoulou; Christina Kostara; Katerina Koutri; Maria G Stathopoulou; Christina Kakavelaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Maturitas     Volume:  67     ISSN:  1873-4111     ISO Abbreviation:  Maturitas     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  166-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Harokopio University, Eleutheriou Venizelou 70, GR17671 Athens, Greece.
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MeSH Terms
Antipsychotic Agents / adverse effects*
Blood Glucose
Body Composition*
Body Weight*
Case-Control Studies
Middle Aged
Obesity / complications,  diet therapy*
Postmenopause / blood
Schizophrenia / complications*,  drug therapy
Reg. No./Substance:
0/Antipsychotic Agents; 0/Blood Glucose

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