| Effects of nutrients and serotonin 5-HT3 antagonism on symptoms evoked by distal gastric distension in humans. | |
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MedLine Citation:
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PMID: 11208541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Distal gastric distension may contribute to meal-related dyspeptic symptoms. This study's aims were to determine the effects of distinct nutrient classes on symptoms induced by distal gastric distension and their dependence on 5-hydroxytryptamine(3) (5-HT3) receptors. Nine healthy subjects rated pain, nausea, and bloating induced by isobaric distal gastric distensions (6-24 mmHg) during duodenal lipid, carbohydrate, protein, or saline perfusion after treatment with placebo or the 5-HT3 receptor antagonist granisetron (10 microg/kg iv). Distensions produced greater pain, nausea, and bloating with lipid at 1.5 kcal/min compared with saline (P < or = 0.02), primarily because of greater distal gastric volumes at each distending pressure. In contrast, carbohydrate and protein had no significant effect. At 3 kcal/min, lipid increased symptoms through a volume-independent as well as a volume-dependent effect. Granisetron did not affect symptom perception or gastric pressure-volume relationships. In conclusion, isobaric distal gastric distension produces more intense symptoms during duodenal lipid compared with saline perfusion. Symptom perception during distal gastric distension is unaffected by 5-HT3 receptor antagonism. |
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Authors:
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U Ladabaum; M B Brown; W Pan; C Owyang; W L Hasler |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 280 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-14 Completed Date: 2001-04-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G201-8 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Internal Medicine, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109-0362, USA. ladabau@itsa.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Balloon Dilatation Carbohydrates / administration & dosage Double-Blind Method Duodenum / physiology Female Granisetron / pharmacology* Humans Intubation, Gastrointestinal Lipids / administration & dosage Male Middle Aged Nausea / etiology Nutritional Physiological Phenomena* Pain / etiology Pressure Proteins / administration & dosage Receptors, Serotonin / drug effects* Receptors, Serotonin, 5-HT3 Serotonin Antagonists / pharmacology* Stomach / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR-00042/RR/NCRR NIH HHS; M01-RR-00079/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carbohydrates; 0/Lipids; 0/Proteins; 0/Receptors, Serotonin; 0/Receptors, Serotonin, 5-HT3; 0/Serotonin Antagonists; 109889-09-0/Granisetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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