Document Detail


Effects of nutrients and serotonin 5-HT3 antagonism on symptoms evoked by distal gastric distension in humans.
MedLine Citation:
PMID:  11208541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Distal gastric distension may contribute to meal-related dyspeptic symptoms. This study's aims were to determine the effects of distinct nutrient classes on symptoms induced by distal gastric distension and their dependence on 5-hydroxytryptamine(3) (5-HT3) receptors. Nine healthy subjects rated pain, nausea, and bloating induced by isobaric distal gastric distensions (6-24 mmHg) during duodenal lipid, carbohydrate, protein, or saline perfusion after treatment with placebo or the 5-HT3 receptor antagonist granisetron (10 microg/kg iv). Distensions produced greater pain, nausea, and bloating with lipid at 1.5 kcal/min compared with saline (P < or = 0.02), primarily because of greater distal gastric volumes at each distending pressure. In contrast, carbohydrate and protein had no significant effect. At 3 kcal/min, lipid increased symptoms through a volume-independent as well as a volume-dependent effect. Granisetron did not affect symptom perception or gastric pressure-volume relationships. In conclusion, isobaric distal gastric distension produces more intense symptoms during duodenal lipid compared with saline perfusion. Symptom perception during distal gastric distension is unaffected by 5-HT3 receptor antagonism.
Authors:
U Ladabaum; M B Brown; W Pan; C Owyang; W L Hasler
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  280     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-04-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G201-8     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Department of Internal Medicine, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109-0362, USA. ladabau@itsa.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Balloon Dilatation
Carbohydrates / administration & dosage
Double-Blind Method
Duodenum / physiology
Female
Granisetron / pharmacology*
Humans
Intubation, Gastrointestinal
Lipids / administration & dosage
Male
Middle Aged
Nausea / etiology
Nutritional Physiological Phenomena*
Pain / etiology
Pressure
Proteins / administration & dosage
Receptors, Serotonin / drug effects*
Receptors, Serotonin, 5-HT3
Serotonin Antagonists / pharmacology*
Stomach / physiology*
Grant Support
ID/Acronym/Agency:
M01-RR-00042/RR/NCRR NIH HHS; M01-RR-00079/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Lipids; 0/Proteins; 0/Receptors, Serotonin; 0/Receptors, Serotonin, 5-HT3; 0/Serotonin Antagonists; 109889-09-0/Granisetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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