| Effects of nutraceuticals on prevalence of metabolic syndrome and on calculated Framingham Risk Score in individuals with dyslipidemia. | |
| | |
MedLine Citation:
|
PMID: 20498621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Nutraceuticals (NUTs) are forms of compounds with biological activity and are used to improve health in dosage largely exceeding those obtainable in food. OBJECTIVES: To investigate whether addition of NUTs to lifestyle management including diet counseling improves lipid profile and reduces cardiovascular risk and prevalence of metabolic syndrome (MetS). METHODS: One thousand, three hundred and eighty, 18-80-year-old nondiabetic participants with dyslipidemia, with or without MetS not requiring pharmacological therapy were assigned to diet; after 2 weeks, 690 patients were also given NUT combination over other 8 weeks. Fasting plasma glucose and lipid compounds were measured by standard methods. Waist circumference, systolic and diastolic blood pressure (BP) were measured at each visit. MetS was defined according to ATPIII guidelines. Ten-year risk of coronary heart disease was calculated using the Framingham Risk Score (FRS). RESULTS: At baseline, NUT patients were older and more dyslipidemic than placebo, with no difference in other cardiovascular risk factors and prevalence of MetS. After 8 weeks, high-density lipoprotein (HDL) cholesterol was increased and diastolic BP, waist girth, triglycerides, total and non-HDL cholesterol were significantly reduced in NUT than in the placebo group, whereas systolic BP and fasting glucose did not change. Prevalence of MetS was also significantly lower in the NUT (36.1%) than in placebo (48.1%, P < 0.05) and reduction in the FRS greater (73.3 vs. 52%, respectively; P < 0.0001). CONCLUSION: In a large clinical sample of patients with moderate cardiovascular risk, combination of NUT with dietary counseling reduces central obesity, improves lipid profile, diastolic BP and FRS, and decreases prevalence of MetS. |
| | |
Authors:
|
Raffaele Izzo; Giovanni de Simone; Renata Giudice; Marcello Chinali; Valentina Trimarco; Nicola De Luca; Bruno Trimarco |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-24 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 1482-7 Citation Subset: IM |
Affiliation:
|
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Blood Pressure Cardiovascular Diseases / epidemiology Cholesterol, HDL / blood Dietary Supplements* Dyslipidemias / blood, diet therapy* Fasting / blood Female Humans Lipids / blood, therapeutic use Male Metabolic Syndrome X / blood, epidemiology*, prevention & control* Middle Aged Obesity, Abdominal / epidemiology Prevalence Risk Triglycerides / blood, therapeutic use Waist Circumference |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, HDL; 0/Lipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated recept...
Next Document: Spontaneous resolution of two dural carotid-cavernous fistulas presenting with optic neuropathy and ...