Document Detail


Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ.
MedLine Citation:
PMID:  1415588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined the effects of 8-epiprostaglandin (PG) F2 alpha, a noncyclooxygenase free radical-catalyzed product of arachidonic acid, on pulmonary vascular tone, its potency, and its mechanism of action. 8-Epi-PGF2 alpha (0.5-20 micrograms) was injected into the pulmonary artery (PA) catheter of 10 rabbits whose lungs were perfused in situ with Krebs-Henseleit buffer solution with 3% bovine serum albumin. PA pressure increased from a baseline of 13.5 +/- 0.6 to 25.6 +/- 2.0 cmH2O with 20 micrograms 8-epi-PGF2 alpha. 8-Epi-PGF2 alpha caused a rapid rise in PA pressure followed by a gradual decline over 40-60 min to baseline levels. Double vascular occlusion revealed a twofold increase in arterial resistance at peak rise in PA pressure. The rise in PA pressure with 20 micrograms 8-epi-PGF2 alpha was fivefold greater than with 20 micrograms of the cyclooxygenase-derived prostaglandin PGF2 alpha. The PA pressure response to 8-epi-PGF2 alpha was not altered by either cyclooxygenase block-ade with 150 microM meclofenamate or alpha-receptor blockade with 70 microM phentolamine, but was fully prevented by 40 microM SQ 29548, a thromboxane receptor antagonist. We conclude that in rabbits 8-epi-PGF2 alpha is a potent vasoconstrictor of the pulmonary vasculature, which appears to be due to the activation of SQ 29548-responsive thromboxane receptors.
Authors:
M Banerjee; K H Kang; J D Morrow; L J Roberts; J H Newman
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-29     Completed Date:  1992-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H660-3     Citation Subset:  IM    
Affiliation:
Department of Medicine, Vanderbilt University School of Medicine, Nashville 37223.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / physiopathology
Blood Pressure / drug effects
Dinoprost / analogs & derivatives*,  pharmacology*
Female
Lung / drug effects*
Meclofenamic Acid / pharmacology
Microcirculation / drug effects
Potassium Chloride / pharmacology
Pulmonary Artery / drug effects
Pulmonary Circulation / drug effects
Rabbits
Grant Support
ID/Acronym/Agency:
HL-19153/HL/NHLBI NIH HHS; HL-39952/HL/NHLBI NIH HHS; K14-02138//PHS HHS
Chemical
Reg. No./Substance:
27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost; 644-62-2/Meclofenamic Acid; 7447-40-7/Potassium Chloride

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