Document Detail

Effects of nortriptyline and paroxetine on QT variability in patients with panic disorder.
MedLine Citation:
PMID:  10875054     Owner:  NLM     Status:  MEDLINE    
This study investigated beat-to-beat QT variability in patients with panic disorder before and after treatment with nortriptyline (n = 13) and paroxetine (n = 16), using an automated algorithm to compute QT intervals. An increase in QT variability appears to be associated with symptomatic patients with dilated cardiomyopathy and also with an increased risk for sudden cardiac death. QTvi (QT variability index: a log ratio of QT variance normalized for mean QT over heart rate variability normalized for mean heart rate) was significantly higher in supine posture in patients with panic disorder treated with nortriptyline (P = 0.006) but not paroxetine. Thus paroxetine may be a better drug of choice especially in patients with coexisting cardiac disease. These findings are important especially in view of the recent reports of increased risk for cardiovascular mortality and sudden death in patients with anxiety and depression. QTvi can be a valuable noninvasive measure of temporal repolarization lability, especially to study the side effects of medications which affect cardiac autonomic function.
V K Yeragani; R Pohl; V C Jampala; R Balon; C Ramesh; K Srinivasan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Depression and anxiety     Volume:  11     ISSN:  1091-4269     ISO Abbreviation:  Depress Anxiety     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-15     Completed Date:  2000-11-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9708816     Medline TA:  Depress Anxiety     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan, USA.
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MeSH Terms
Antidepressive Agents, Tricyclic / adverse effects*,  therapeutic use
Death, Sudden, Cardiac / etiology
Electrocardiography / drug effects*
Heart Rate / drug effects
Long QT Syndrome / chemically induced*,  diagnosis
Nortriptyline / adverse effects*,  therapeutic use
Panic Disorder / drug therapy*,  psychology
Paroxetine / adverse effects*,  therapeutic use
Risk Factors
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Grant Support
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 0/Serotonin Uptake Inhibitors; 61869-08-7/Paroxetine; 72-69-5/Nortriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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