| Effects of a normolipidic diet containing trans fatty acids during perinatal period on the growth, hippocampus fatty acid profile, and memory of young rats according to sex. | |
| | |
MedLine Citation:
|
PMID: 22169117 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate whether dietary trans fatty acids (TFAs) are incorporated in the hippocampus and its effects on the growth and aversive and spatial memories of young rats. METHODS: Wistar rat offspring whose mothers were fed with normolipidic diets containing soybean oil (soy group) or hydrogenated vegetable oil (trans group) during gestation and lactation were used. Male and female pups received the same diets as their mothers until the end of behavioral testing. The composition of fatty acids in the total lipids of the diets and hippocampus was quantified by gas chromatography. The results were evaluated by Student's t test or analysis of variance followed by the Bonferroni correction. RESULTS: The trans male and female body weights were higher during lactation and after weaning, with trans males having the lower body weight of the two. There was incorporation of 0.11% and 0.17% of TFAs in the hippocampi of male and female rats, respectively. During passive avoidance test, there was no significant difference. In the water maze test, there was no significant difference between male groups in the training and retention phases, except on day 4, when there was a significant decrease in latency in trans males. Trans females were worse on day 2 only and showed an improvement in spatial memory during the probe trial. CONCLUSION: The TFAs were incorporated in small amounts in the hippocampus and did not affect aversive memory. However, spatial memory was modified in young rats fed with a diet rich in TFAs. These findings suggested that, in addition to the TFA content of the diet provided, it is important to consider the provision of essential fatty acids and the ω-6/ω-3 ratio. |
| | |
Authors:
|
Amanda Santos de Souza; Mônica Santos Rocha; Maria das Graças Tavares do Carmo |
Related Documents
:
|
21736807 - The effect of choline and cystine on the utilisation of methionine for protein accretio... 21703027 - High fat diet intake during pre and periadolescence impairs learning of a conditioned p... 3098177 - R-galactonolactone in experimental galactosemic animals. 21207517 - Dietary supplements and human health: for better or for worse? 1614947 - Research note: effect of 2,4-dinitrophenol on growth and body composition of broilers. 11067787 - Alcohol consumption raises hdl cholesterol levels by increasing the transport rate of a... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
|
Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: - ISSN: 1873-1244 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8802712 Medline TA: Nutrition Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Laboratório de Farmacologia da Neuroplasticidade e do Comportamento, Instituto de Ciências Biomédicas, CCS, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, Brazil; Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, CCS, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Primitive cerebral melanoma: A diagnostic and management challenge. About 2 cases.
Next Document: Proactive screening identifies alarming prevalence of malnutrition among hospitalized patients-Actio...