Document Detail


Effects of normal blood pressure, prehypertension, and hypertension on coronary microvascular function.
MedLine Citation:
PMID:  17283278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The assessment of coronary flow reserve (CFR) by transthoracic Doppler echocardiography has recently been introduced into clinical practice, and reduced CFR has been suggested to be a sensitive indicator of hypertensive end-organ damage; however, to date, this methodology has not been used to evaluate CFR in subjects with prehypertension. Accordingly, the present study was designed to evaluate CFR in subjects with prehypertension. METHODS AND RESULTS: We measured CFR of 40 subjects with prehypertension, 60 patients with hypertension, and 50 normotensive healthy volunteers using transthoracic Doppler echocardiography. None of the subjects had any systemic disease. Age, gender, body mass index, heart rate, lipid profiles, fasting glucose levels, and hemoglobin were similar among the 3 groups. CFR was significantly lower in the hypertension group than in the prehypertension and control groups; in addition, it was significantly lower in subjects with prehypertension than in control subjects (2.23+/-0.47, 2.54+/-0.48, and 2.91+/-0.53, respectively). Furthermore, we found that prehypertension (beta=-0.31, P<0.01) and hypertension (beta=-0.57, P<0.01) were significant predictors of lower CFR in a multivariable model that adjusted for other variables. CFR was significantly and inversely correlated with age (r=-0.20, P=0.01), systolic blood pressure (r=-0.51, P<0.01), diastolic blood pressure (r=-0.47, P<0.01), high-sensitivity C-reactive protein levels (r=-0.21, P=0.01), left atrium diameter (r=-0.22, P<0.01), mitral E deceleration time (r=-0.19, P=0.02), and mitral A velocity (r=-0.27, P<0.01), whereas mitral E/A ratio was significantly and positively correlated with CFR (r=0.26, P<0.01). CONCLUSIONS: CFR is impaired in subjects with prehypertension, but this impairment is not as severe as that in hypertension.
Authors:
Dogan Erdogan; Ibrahim Yildirim; Ozgur Ciftci; Ismail Ozer; Mustafa Caliskan; Hakan Gullu; Haldun Muderrisoglu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Circulation     Volume:  115     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-06     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-9     Citation Subset:  AIM; IM    
Affiliation:
Baskent University, Konya Teaching and Medical Research Center, Cardiology Department, Hoca Cihan Mah, Saray Cad, No. 1, Selcuklu, Konya, Turkey. aydoganer@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Coronary Circulation / physiology*
Coronary Vessels / physiology*
Female
Humans
Hypertension / physiopathology*
Male
Microcirculation / physiology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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