| Effects of noradrenaline and carbachol on temperature regulation of cold-stressed and cold-acclimated rats. | |
| | |
MedLine Citation:
|
PMID: 465885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1 Noradrenaline (20 micrograms) and carbachol (1 microgram) injected into the anterior hypothalamus of rats at an ambient temperature of 23 degrees C evoked significant falls in core temperature and increases in tail temperature. 2 When rats were cold-stressed (4 degrees C for 90 min) or cold-acclimated (4 degrees C for 4 weeks) and the above amine injections repeated, only carbachol evoked significant falls in core temperature and neither amine increased tail temperature. 3 Central injections of noradrenaline and carbachol also evoked increases in plasma glucose concentrations but not plasma non-esterified fatty acid (NEFA) concentrations in control, acutely cold-stressed and cold-acclimated rats. 4 Although concentrations of plasma glucose and blood lactate of rats were unaffected by cold exposure to 4 degrees C for 1 to 28 days, glucose oxidation rate of both cold-stressed and cold-acclimated rats was significantly greater than in rats at 23 degrees C. Concentrations of plasma NEFA were increased after 1 to 28 days of cold exposure. |
| | |
Authors:
|
S Poole; J D Stephenson |
Related Documents
:
|
2631155 - Brown adipose tissue thermogenesis above the lower critical temperature. 10644645 - Influence of temperature on activity of the isolated whole bladder preparation of neona... 2339475 - Effects of ultrasound on placental transfer during the last third of gestation in the rat. 971755 - Resistance of cold-exposed rats to aflatoxin. 1150935 - Learned helplessness in the rat. 6477535 - Urinary n-acetyl-beta-d-glucosaminidase in streptozotocin-induced diabetic rats. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of pharmacology Volume: 66 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1979 Jun |
Date Detail:
|
Created Date: 1979-10-26 Completed Date: 1979-10-26 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 307-15 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acclimatization Animals Blood Glucose / blood Body Temperature / drug effects Body Temperature Regulation / drug effects* Body Weight / drug effects Carbachol / pharmacology* Cold Temperature Fatty Acids, Nonesterified / blood Glycolysis / drug effects Hypothalamus Male Norepinephrine / pharmacology* Rats Stress, Physiological / physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 51-41-2/Norepinephrine; 51-83-2/Carbachol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On the distribution of [met5]- and [leu5]-enkephalins in the brain of the rat, guinea-pig and calf.
Next Document: Improved insulin receptor assay: effects of an antidiabetic sulphonylurea on liver membrane insulin ...