Document Detail

Effects of noradrenaline and carbachol on temperature regulation of cold-stressed and cold-acclimated rats.
MedLine Citation:
PMID:  465885     Owner:  NLM     Status:  MEDLINE    
1 Noradrenaline (20 micrograms) and carbachol (1 microgram) injected into the anterior hypothalamus of rats at an ambient temperature of 23 degrees C evoked significant falls in core temperature and increases in tail temperature. 2 When rats were cold-stressed (4 degrees C for 90 min) or cold-acclimated (4 degrees C for 4 weeks) and the above amine injections repeated, only carbachol evoked significant falls in core temperature and neither amine increased tail temperature. 3 Central injections of noradrenaline and carbachol also evoked increases in plasma glucose concentrations but not plasma non-esterified fatty acid (NEFA) concentrations in control, acutely cold-stressed and cold-acclimated rats. 4 Although concentrations of plasma glucose and blood lactate of rats were unaffected by cold exposure to 4 degrees C for 1 to 28 days, glucose oxidation rate of both cold-stressed and cold-acclimated rats was significantly greater than in rats at 23 degrees C. Concentrations of plasma NEFA were increased after 1 to 28 days of cold exposure.
S Poole; J D Stephenson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  66     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  307-15     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / blood
Body Temperature / drug effects
Body Temperature Regulation / drug effects*
Body Weight / drug effects
Carbachol / pharmacology*
Cold Temperature
Fatty Acids, Nonesterified / blood
Glycolysis / drug effects
Norepinephrine / pharmacology*
Stress, Physiological / physiopathology*
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 51-41-2/Norepinephrine; 51-83-2/Carbachol

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