Document Detail

Effects of nonylphenol and 17beta-estradiol on vitellogenin synthesis and testis morphology in male platyfish Xiphophorus maculatus.
MedLine Citation:
PMID:  10607527     Owner:  NLM     Status:  MEDLINE    
Nonylphenol has been found to exert estrogenic effects in fish and may influence the fertility of male fish. In the present study, the effects of nonylphenol and 17beta-estradiol on vitellogenin synthesis and testis morphology in platyfish Xiphophorus maculatus were investigated. Vitellogenin was observed in the plasma of all fish exposed to nonylphenol or 17beta-estradiol. Exposure to 17beta-estradiol resulted in a significant reduction in the gonadosomatic index. A tendency for a dose-dependent reduction in the gonadosomatic index in the nonylphenol exposed groups was observed. Histological examination revealed dose-dependent effects of nonylphenol on the testis structure. The testes of control fish contained numerous cysts with spermatogenetic cells. The testes of fish exposed to nonylphenol or 17beta-estradiol showed a decrease in the number of cysts concomitant with an increase in the amount of hypertrophied Sertoli cells present. Formation of spermatozeugmata is compulsory for this species, but free spermatozoa were observed in the efferent ducts of the treated fish. The study indicates that nonylphenol has estrogenic potency, and that both nonylphenol and 17beta-estradiol have marked effects on the testis morphology of X. maculatus. The ambient concentration of nonylphenol was measured by high pressure liquid chromatography during the experiment. The measurements revealed that the actual concentrations of nonylphenol in the water were about 30-40 % of the nominal concentrations.
K Kinnberg; B Korsgaard; P Bjerregaard; A Jespersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  203     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  171-81     Citation Subset:  IM    
Institute of Biology, Odense University, DK-5230 Odense M, Denmark and Institute of Zoology, University of Copenhagen, DK-2100 Copenhagen O, Denmark.
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MeSH Terms
Cyprinodontiformes / anatomy & histology*,  metabolism
Electrophoresis, Polyacrylamide Gel
Estradiol / toxicity*
Estradiol Congeners / toxicity*
Microscopy, Electron
Phenols / toxicity*
Sertoli Cells / drug effects,  metabolism,  ultrastructure
Testis / anatomy & histology,  drug effects*,  metabolism,  ultrastructure
Vitellogenins / biosynthesis*
Water Pollutants / adverse effects
gamma-Glutamyltransferase / metabolism
Reg. No./Substance:
0/Estradiol Congeners; 0/Phenols; 0/Vitellogenins; 0/Water Pollutants; 25154-52-3/nonylphenol; 50-28-2/Estradiol; EC

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