| Effects of the nonsteroidal anti-inflammatory drug piroxicam on energy metabolism in the perfused rat liver. | |
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MedLine Citation:
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PMID: 8665405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The actions of piroxicam, a nonsteroidal and noncarboxylic anti-inflammatory drug, on the metabolism of the isolated perfused rat liver were investigated. The main purpose was to verify if piroxicam is also active on glycogenolysis and energy metabolism, as demonstrated for several carboxylic nonsteroidal anti-inflammatories. 2. Piroxicam increased oxygen consumption in livers from both fed and fasted rats. 3. Piroxicam increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). 4. Gluconeogenesis from lactate plus pyruvate was inhibited. 5. The action of piroxicam on oxygen consumption was blocked by antimycin A, but not by atractyloside. 6. The action of piroxicam in the perfused rat liver metabolism seems to be a consequence of its action on mitochondria. 7. It can be concluded that inhibition of energy metabolism and stimulation of glycogenolysis are not specific properties of carboxylic nonsteroidal anti-inflammatory drugs. |
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Authors:
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C L Salgueiro-Pagadigorria; J Constantin; A Bracht; E A Nascimento; E L Ishii-Iwamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Volume: 113 ISSN: 1367-8280 ISO Abbreviation: Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-08-08 Completed Date: 1996-08-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9516060 Medline TA: Comp Biochem Physiol C Pharmacol Toxicol Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 93-8 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Maringá, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Anti-Bacterial Agents / toxicity Anti-Inflammatory Agents, Non-Steroidal / toxicity* Antimycin A / toxicity Atractyloside / toxicity Drug Interactions Energy Metabolism / drug effects* Fasting Gluconeogenesis / drug effects Glucose / metabolism Glycogen / metabolism Lactates / metabolism Lactic Acid Liver / drug effects*, metabolism Male Mitochondria, Liver / drug effects, metabolism NAD / metabolism NADP / metabolism Oxygen Consumption / drug effects Perfusion Piroxicam / toxicity* Pyruvates / metabolism Pyruvic Acid Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Lactates; 0/Pyruvates; 127-17-3/Pyruvic Acid; 17754-44-8/Atractyloside; 36322-90-4/Piroxicam; 50-21-5/Lactic Acid; 50-99-7/Glucose; 53-59-8/NADP; 53-84-9/NAD; 56-65-5/Adenosine Triphosphate; 642-15-9/Antimycin A; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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