Document Detail

Effects of nonionic and ionic surfactants on survival, oxidative stress, and cholinesterase activity of planarian.
MedLine Citation:
PMID:  17905407     Owner:  NLM     Status:  MEDLINE    
Eight widely used surfactants (cetyltrimethylammonium bromide; CTAB, benzethonium chloride; Hyamine 1622, 4-nonylphenol; NP, octylphenol ethoxylate; Triton X-100, dodecylbenzene sulfonate; LAS, lauryl sulfate; SDS, pentadecafluorooctanoic acid; PFOA, and perfluorooctane sulfonate; PFOS) were selected to examine their acute toxicities and effects on oxidative stress and cholinesterase (ChE) activities in Dugesia japonica. The differences in acute toxicity among eight surfactants to planarians were at least in the range of three orders of magnitudes. The toxicity rank of surfactants according to estimated 48-h LC(50) was SDS>NP>LAS>Hyamine 1622>CTAB>Triton X-100>PFOS>PFOA. The toxicity rank of surfactants according to 96-h LC(50) was as follows: SDS>CTAB>NP>LAS>Hyamine 1622>Triton X-100>PFOS>PFOA. There were significant increases in catalase activities in planarians exposed to LAS at nominal concentrations of 0.5 or 1 mgl(-1) and to PFOS at nominal concentrations of 5 or 10 mgl(-1) after 48-h exposure. Inhibitions of ChE activities were found in planarians exposed to Hyamine 1622 at all concentrations tested, to PFOS at nominal concentration of 10 mgl(-1), to PFOA at nominal concentrations of 50 or 100 mgl(-1) and to NP at nominal concentration of 0.5 mgl(-1). A significant increase in ChE activities was also observed in planarian exposed to Triton X-100 at nominal concentration of 5 mgl(-1). The implication of ChE inhibition by NP, PFOS and PFOA on neurological and behavioral effects in aquatic animals requires further investigation.
Mei-Hui Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-01
Journal Detail:
Title:  Chemosphere     Volume:  70     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1796-803     Citation Subset:  IM    
Environmental Toxicology Laboratory, Department of Geography, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei 106, Taiwan.
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MeSH Terms
Benzethonium / toxicity
Catalase / metabolism
Cetrimonium Compounds / toxicity
Cholinesterases / metabolism*
Fluorocarbons / toxicity
Lethal Dose 50
Lipid Peroxidation / drug effects
No-Observed-Adverse-Effect Level
Octanoic Acids / toxicity
Oxidative Stress*
Phenols / toxicity
Planarians / drug effects*,  metabolism
Proteins / metabolism
Sulfonic Acids / toxicity
Superoxide Dismutase / metabolism
Surface-Active Agents / toxicity*
Reg. No./Substance:
0/Cetrimonium Compounds; 0/Fluorocarbons; 0/Octanoic Acids; 0/Phenols; 0/Proteins; 0/Sulfonic Acids; 0/Surface-Active Agents; 121-54-0/Benzethonium; 25154-52-3/nonylphenol; 335-67-1/perfluorooctanoic acid; 6899-10-1/cetrimonium; EC; EC Dismutase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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