| Effects of non-depolarizing neuromuscular blocking agents on the cardiac vagus nerve in the guineapig. | |
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MedLine Citation:
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PMID: 7437219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of gallamine, metocurine, pancuronium, tubocurarine and atropine to block the response to postganglionic stimulation of the vagus nerve were measured in isolated, spontaneously beating guineapig atria. From analysis of the results in conjunction with those of earlier assays of concentrations that block effects of preganglionic vagal stimulation, it was concluded that only tubocurarine possessed ganglionic blocking activity. From calculation of the extent of block of muscarinic receptors at drug concentrations which blocked the response to postganglionic vagal stimulation, it was concluded that gallamine and pancuronium have an antivagal action exerted most probably on the postganglionic nerve terminal, and that this action is the most likely explanation of the tachycardia seen clinically with these two drugs. |
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Authors:
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S L Son; D R Waud |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 52 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1980 Oct |
Date Detail:
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Created Date: 1981-02-19 Completed Date: 1981-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 981-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Autonomic Fibers, Postganglionic / drug effects Depression, Chemical Dose-Response Relationship, Drug Electric Stimulation Female Guinea Pigs Heart / innervation* Heart Atria / innervation Hexamethonium Compounds / pharmacology Male Neuromuscular Blocking Agents / pharmacology* Vagus Nerve / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 0/Neuromuscular Blocking Agents; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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