Document Detail

Effects of nocturnal oxygen therapy on sleep apnea syndrome in peritoneal dialysis patients.
MedLine Citation:
PMID:  18826859     Owner:  NLM     Status:  MEDLINE    
Sleep apnea syndrome (SAS) is common in patients with end-stage renal disease (ESRD). Although the treatment of choice is continuous positive airway pressure (CPAP) particularly for obstructive SAS, long-term compliance is not satisfactory. We investigated the effectiveness of nocturnal oxygen therapy on sleep apnea and autonomic nervous dysfunction in peritoneal dialysis (PD) patients with SAS. METHODS: 40 patients on PD in our outpatient clinic were screened for SAS by pulse oximetry. We set the indication for nocturnal oxygen therapy at 4% oxygen desaturation index (4% ODI; defined as the number of falls of oxygen saturation > or = 4% per hour) > 5 or average nocturnal saturation < 95%. For SAS patients, 2 l per minute of oxygen was given during sleep and polysomnography was performed before and 1 month after oxygen administration. The heart rate variability was analyzed to assess autonomic nervous activity. RESULTS: 23 patients fulfilled the indication for oxygen therapy and 11 patients agreed to participate in the study. After oxygen therapy, the apnea-hypopnea index (AHI) and the frequencies of hypopnea and central apnea were significantly decreased (AHI: from 31.1 +/- 8.8 to 12.7 +/- 8.5, p < 0.01; hypopnea: from 19.5 +/- 4.3 to 3.5 +/- 3.2, p < 0.01; central apnea: from 4.0 +/- 4.0 to 0.8 +/- 1.2, p < 0.05), whereas that of obstructive apnea was not changed. An analysis of heart rate variability showed that oxygen therapy did not alter autonomic activity after 1 month of oxygen therapy. CONCLUSIONS: Nocturnal oxygen therapy decreases hypopnea and central apnea in PD patients with SAS. Nocturnal oxygen therapy may be useful for the treatment of SAS in PD patients, particularly when central apnea and hypopnea are predominant.
T Kumagai; Y Ishibashi; H Kawarazaki; W Kawarazaki; H Shimizu; S Kaname; T Fujita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nephrology     Volume:  70     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  332-9     Citation Subset:  IM    
Division of Total Renal Care Medicine, The University of Tokyo, Tokyo, Japan.
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MeSH Terms
Kidney Failure, Chronic / complications,  physiopathology,  therapy
Middle Aged
Oxygen Inhalation Therapy / methods*
Peritoneal Dialysis / adverse effects*
Sleep Apnea Syndromes / etiology,  physiopathology,  therapy*
Statistics, Nonparametric
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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