| Effects of nociceptin and analogues of nociceptin upon spontaneous dorsal root activity recorded from an in vitro preparation of rat spinal cord. | |
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MedLine Citation:
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PMID: 14550927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 17 amino acid peptide nociceptin has been implicated in pain modulation in the central nervous system. The effects of bath applied nociceptin, and some analogues of nociceptin, upon spontaneous lumbar dorsal root activity have been investigated in an isolated preparation of rat spinal cord. Nociceptin was found to reversibly depress spontaneous dorsal root activity at concentrations of 1.0 microM and 10.0 microM (IC50 2.0 microM), whereas acetyl-nociceptin at concentrations up to 10 microM had no detectable effect. Omission of the last four amino acids (nociceptin 1-13), increased the potency of the effect upon dorsal root activity by approximately 100-fold (IC50 30 nM), but activity was lost when only the first seven amino acids of the nociceptin molecule (nociceptin 1-7) were tested. |
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Authors:
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Rebecca Maile; Robert J Walker; Ram P Sharma; Jeff Bagust |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 350 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-10 Completed Date: 2003-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 190-2 Citation Subset: IM |
Affiliation:
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Cell Sciences Division, School of Biological Sciences, Bassett Crescent East, Southampton University, Southampton SO16 7PX, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Electric Stimulation Opioid Peptides / pharmacology* Organ Culture Techniques Peptides / pharmacology Rats Rats, Wistar Spinal Cord / physiology Spinal Nerve Roots / drug effects*, physiology* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Opioid Peptides; 0/Peptides; 0/Vasodilator Agents; 0/nociceptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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