Document Detail

Effects of nitrous oxide on IOP and pupillary diameter in dogs anesthetized with varying concentrations of desflurane.
MedLine Citation:
PMID:  18435659     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the present study was to evaluate the effects of nitrous oxide on IOP and pupillary diameter (PD) of dogs anesthetized with varying desflurane concentrations. ANIMALS STUDIED: Twenty adult Mongrel dogs were used. METHODS: They were anesthetized with propofol (10 mg/kg, IV) and maintained with varying concentrations of desflurane (1.6, 1.4, and 1.2 MAC) diluted in 100% oxygen (G1) or in 70% nitrous oxide and 30% oxygen (G2) (30 mL/kg/min). IOP was measured by applanation tonometry and horizontal PD was taken with a caliper adjacent to the cornea. Mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), and end-tidal CO(2) (etCO2) were also measured. All parameters were measured at T0, T30, T45, and T60 time points. One-way repeated measures anova and the t-test were used to assess statistical differences (P < 0.05). RESULTS: T30, T45, and T60 IOP measures were within normal limits for both groups and IOP did not differ between groups at any time. There was a significant decrease in PD in G1 between T0 and T30, T45 and T60, and also between T30 and T60. PD did not differ between groups. All vital parameters were within normal limits throughout anesthesia. CONCLUSIONS: Administration of nitrous oxide with desflurane results in maintenance of normal IOP and prevents a decrease in horizontal PD during anesthesia. Therefore, this may be a suitable protocol in dogs undergoing intraocular surgeries that require mydriasis and maintenance of normal IOP.
Denise E Almeida; Celina T Nishimori; Arianne P Oriá; Danielli P Paula; Newton Nunes; José L Laus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary ophthalmology     Volume:  11     ISSN:  1463-5224     ISO Abbreviation:  Vet Ophthalmol     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-04-25     Completed Date:  2008-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887377     Medline TA:  Vet Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
Michigan State University, East Lansing, MI, USA.
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MeSH Terms
Analysis of Variance
Anesthetics, Inhalation / pharmacology*
Dogs / physiology*
Dose-Response Relationship, Drug
Heart Rate / drug effects,  physiology
Intraocular Pressure / drug effects*
Isoflurane / analogs & derivatives*,  pharmacology
Nitrous Oxide
Pupil / drug effects,  physiology
Respiration / drug effects
Reg. No./Substance:
0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide; 26675-46-7/Isoflurane; 57041-67-5/desflurane

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