| Effects of nitroprusside and nitroglycerin on coronary blood flow in stenotic arteries: study in patients with single-vessel coronary artery disease. | |
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MedLine Citation:
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PMID: 18688061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the effect of intravenous sodium nitroprusside and nitroglycerin on coronary blood flow distal to a severe coronary artery stenosis. METHODS: Parameters of coronary arteries and coronary blood flow were measured distally to the stenosis during nitroprusside and nitroglycerin infusions in a dose producing a 25% decrease in mean arterial blood pressure in patients with single-vessel coronary artery disease. RESULTS: Twenty patients (19 male, mean age 54.25 +/- 9.72 years), with a 52-90% diameter reduction of the left anterior descending (LAD) artery were included in this study. Compared to baseline, only nitroglycerin produced a significant increase in the minimal lumen diameter of 18.02 +/- 4.26% and minimal lumen area of 42.69 +/- 10.18%. Both medications increased the distal vessel diameter. Nitroglycerin also produced a significant increase in the reference segment diameter. Despite the substantial pressure drop, there was no decrease in coronary blood flow (at rest or during hyperemia produced by intracoronary adenosine) or coronary flow reserve with both drugs. Nitroglycerin increased the hyperemic diastolic/systolic velocity ratio by 21.57 +/- 8.97% (p < 0.05). Compared to baseline, there were significant reductions in the total and minimal coronary vessel resistance indices for both nitroprusside and nitroglycerin. CONCLUSION: In patients with a severe single coronary atherosclerotic lesion, intravenous infusion of nitroprusside and nitroglycerin in a dose sufficient to produce a substantial drop in mean arterial pressure does not lead to any decrease in coronary blood flow or coronary flow reserve. |
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Authors:
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Plamen Gatzov; Vassilis Voudris; John Skoularikis; Gentcho Gentchev; Athanassios Manginas; Dennis V Cokkinos |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 20 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-08 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 391-5 Citation Subset: IM |
Affiliation:
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Cardiology Clinic, National Heart Hospital, 1309, Sofia, Bulgaria. plamengatzov@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Coronary Circulation / drug effects* Coronary Stenosis / drug therapy* Coronary Vessels / drug effects* Female Humans Infusions, Intravenous Male Middle Aged Nitroglycerin / administration & dosage, pharmacology* Nitroprusside / pharmacology* Vasodilator Agents / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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