| Effects of nitroglycerin and nifedipine on coronary and systemic hemodynamics during transient coronary artery occlusion. | |
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MedLine Citation:
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PMID: 2967625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitroglycerin (NTG) and nifedipine (NIF) have the potential to augment coronary blood flow in addition to reducing peripheral determinants of myocardial oxygen demand as a synergistic protective mechanism during ischemia. To examine these effects, systemic and coronary hemodynamic responses were measured continuously before and during brief periods of myocardial ischemia induced by left anterior descending coronary balloon occlusion in 26 patients undergoing angioplasty (PTCA). Data were compared for two matched occlusion periods, one control and one "drug" occlusion. In 17 patients (NTG group), 200 micrograms of intracoronary NTG was given immediately before coronary occlusion. In nine patients (NIF group), 10 mg of sublingual NIF was given 15 minutes before the "drug" occlusion. NTG significantly but transiently reduced mean arterial pressure (91 +/- 11 to 82 +/- 15 mm Hg, p less than 0.05) and augmented basal coronary blood flow (95 +/- 38 to 127 +/- 54 ml/min, p less than 0.05) but did not alter great vein blood flow (59 +/- 29 vs 61 +/- 29 ml/min) or coronary occlusion pressure (25 +/- 7 to 24 +/- 7 mm Hg) during ischemia. NIF significantly reduced systolic, diastolic, and mean arterial pressure (119 +/- 21 to 95 +/- 8 mm Hg, p less than 0.001) and heart rate-pressure product from control. NIF maintained basal great vein blood flow (125 +/- 41 to 106 +/- 57 ml/min) during reduced myocardial oxygen demand, but did not affect great vein blood flow (73 +/- 29 to 79 +/- 37 ml/min) or coronary occlusion pressures during ischemia.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M J Kern; U Deligonul; A Labovitz; G Gabliani; M Vandormael; H L Kennedy |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 115 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-06-28 Completed Date: 1988-06-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1164-70 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, St. Louis University School of Medicine, MO. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angioplasty, Balloon* Blood Pressure / drug effects Collateral Circulation / drug effects Coronary Circulation / drug effects Coronary Disease / physiopathology*, therapy Electrocardiography Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Male Middle Aged Myocardial Contraction / drug effects Nifedipine / pharmacology* Nitroglycerin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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21829-25-4/Nifedipine; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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