Document Detail

Effects of nitroglycerin on isometric exercise.
MedLine Citation:
PMID:  6401906     Owner:  NLM     Status:  MEDLINE    
Eight patients with ischemic heart disease performed isometric handgrip of five minutes' duration at 30% of their maximum voluntary contraction, before and after administration of 0.4 mg sublingual nitroglycerin (NTG). Although isometric exercise resulted in similar rise of left ventricular systolic pressure (LVSP) before and after NTG, the level of LVSP during the post NTG effort was lower. Heart rate, cardiac index, stroke index, left ventricular stroke work index, and systemic resistance were not different during the pre- and post NTG exercise. Left ventricular end-diastolic pressure rose to a significantly lower level (18.3 +/- 14.4 mm Hg) during the post NTG handgrip than during the pre NTG effort (31.4 +/- 17.6 mm Hg, P less than 0.005). It is concluded that NTG reduces preload and afterload both at rest and during isometric exercise and improves left ventricular performance during isometric exercise.
A P Flessas; T J Ryan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  105     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-42     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Coronary Disease / diagnosis,  drug therapy*,  physiopathology
Heart Rate
Isometric Contraction*
Middle Aged
Nitroglycerin / therapeutic use*
Physical Exertion*
Stroke Volume
Reg. No./Substance:

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