Document Detail


Effects of nitroglycerin and diltiazem on well-developed coronary collateral circulation in conscious dogs.
MedLine Citation:
PMID:  1909843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present study was to compare the effects of nitroglycerin and diltiazem on coronary collateral circulation. Studies were conducted in 8 conscious dogs instrumented for the measurement of left circumflex coronary artery (LCCA) flow, subendocardial segment lengths in areas perfused by the LCCA, and left anterior descending coronary artery (LAD). Brief, repeated LCCA occlusions sufficiently developed collateral vessels for the resting metabolic requirement in the LCCA region. One week following the cessation of repeated LCCA occlusions, two-minute coronary occlusions with and without drug pretreatment were performed on separate days. The ischemic responses to coronary occlusions were not altered by diltiazem (50 micrograms/kg, IV), but nitroglycerin (5 micrograms/kg, IV) attenuated myocardial ischemia definitely. The authors conclude that nitroglycerin produces greater effects than diltiazem in attenuating myocardial ischemia in the collateral dependent zone when effects of each drug on systemic and coronary circulation were minimized by pretreatment with small doses.
Authors:
M Fujita; A Mikuniya; D P McKown; M D McKown; D Franklin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Angiology     Volume:  42     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-16     Completed Date:  1991-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  628-38     Citation Subset:  IM    
Affiliation:
Dalton Research Center, University of Missouri-Columbia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Collateral Circulation / drug effects*,  physiology
Coronary Circulation / drug effects*,  physiology
Coronary Disease / physiopathology
Diltiazem / pharmacology*
Dogs
Hemodynamics / drug effects,  physiology
Nitroglycerin / pharmacology*
Time Factors
Wakefulness / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
HL 32800/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
42399-41-7/Diltiazem; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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