| Effects of nitroglycerin on central haemodynamics and VA/Q distribution early after coronary bypass surgery. | |
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MedLine Citation:
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PMID: 6815975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central haemodynamics and ventilation-perfusion (VA/Q) distribution were studied in nine patients, 21 h after coronary bypass surgery, before and during nitroglycerin (TNG) infusion. VA/Q distributions were established with the multiple inert gas elimination technique of Wagner and West. Administration of TNG resulted in a decrease in mean arterial pressure, a slight reduction in cardiac output and stroke volume and a significant increase in heart rate, possibly explained by an initial relative hypovolaemia. Pulmonary arterial pressures and filling pressures for the right and left ventricles decreased significantly. There was a significant reduction in PaO2 and an increase in venous admixture (QVA/QT) from 11.3 to 16.5% of cardiac output. This was mainly due to an initial SF6-shunt of 6.4% increasing to 12.8%. Only 3.5% of cardiac output during TNG was due to perfusion of hypoventilated areas. The mean for the control Q-distribution was 0.88 with a mean log s.d. of +/- 1.14, indicating VA/Q-mismatch and did not change significantly. The reduction of pressures in the pulmonary vascular bed was accompanied by increased ventilation of areas with high VA/Q. |
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Authors:
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E Anjou-Lindskog; L Broman; A Holmgren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 26 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 489-97 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiac Output / drug effects Coronary Artery Bypass* Hemodynamics / drug effects* Humans Male Middle Aged Nitroglycerin / pharmacology* Oxygen / blood Postoperative Period Pulmonary Gas Exchange / drug effects* |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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