Document Detail


Effects of nitrogen dioxide on allergic airway responses in subjects with asthma.
MedLine Citation:
PMID:  16340706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We sought to determine whether nitrogen dioxide (NO2) can enhance airway inflammation after allergen challenge in asthmatic subjects. METHODS: Fifteen house-dust-mite (HDM)-sensitive asthmatic subjects were exposed for 3 hours to filtered air or 0.4 ppm NO2, followed by inhalational challenge with HDM allergen. Markers of inflammation were measured in sputum at 6 hours and 26 hours after allergen challenge. RESULTS: After exposure to NO2, eosinophil concentration decreased significantly in the 6-hour postallergen sputum. No significant NO2-related difference was observed for other variables. CONCLUSIONS: Our results suggest that, in most asthmatic individuals, multi-hour exposure to a high ambient concentration of NO2 does not enhance the inflammatory response to subsequent inhaled allergen as assessed by cell distribution in induced sputum. Because the decrease in airway eosinophils has been reported in previous animal studies, future research should be directed toward the mechanism of this effect.
Authors:
Allyson Witten; Colin Solomon; Emilio Abbritti; Mehrdad Arjomandi; Wenwu Zhai; Michael Kleinman; John Balmes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  47     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1250-9     Citation Subset:  IM    
Affiliation:
Lung Biology Center and Division of Occupational and Environmental Medicine, University of California, San Francisco, California 94143-0843, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma*
Eosinophils / immunology,  secretion
Female
Humans
Hypersensitivity / immunology*
Male
Middle Aged
Nitrogen Dioxide / metabolism*
Pneumonia
Pyroglyphidae
Questionnaires
Respiratory System / immunology*
Grant Support
ID/Acronym/Agency:
M01RR00083-41/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
10102-44-0/Nitrogen Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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