| Effects of nitric oxide synthase inhibition on regional cerebral blood flow and vascular resistance in conscious and isoflurane-anesthetized rats. | |
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MedLine Citation:
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PMID: 7692769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide is an important regulator of the regional cerebral vascular tone. We compared the magnitude of nitric oxide-related changes in the vascular tone by studying the regional cerebral blood flow (rCBF) and vascular resistance in conscious and isoflurane-anesthetized rats by using a nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME). In the conscious group (n = 12), after cannulation of a femoral artery and two veins under isoflurane anesthesia, rats were allowed to remain awake for 90 min. In the anesthetized group (n = 18), rats were anesthetized with 2% isoflurane and mechanically ventilated. Six rats in each group were treated with L-NAME (2 mg.kg-1 x min-1 for 30 min) or saline. For the remaining rats in the isoflurane-anesthetized group (n = 6), arterial blood pressure was increased by phenylephrine infusion to the same level as that in the L-NAME-treated, isoflurane-anesthetized rats. Regional vascular resistance was determined by the ratio of mean arterial blood pressure and rCBF which was measured by [14C]iodoantipyrine. L-NAME significantly increased mean arterial blood pressure in both the conscious (123 to 158 mm Hg) and anesthetized (82 to 144 mm Hg) rats. Regional vascular resistance increased significantly in all 12 brain regions studied with the average value increasing from 1.19 +/- 0.33 mm Hg.mL-1 x min x 100 g to 2.22 +/- 0.48 (P < 0.0001) in the conscious and from 0.78 +/- 0.27 to 1.61 +/- 0.48 (P < 0.0001) in the isoflurane-anesthetized rats.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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H M Wei; H R Weiss; A K Sinha; O Z Chi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 77 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-11-18 Completed Date: 1993-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 880-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903-0019. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Oxidoreductases
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antagonists & inhibitors* Anesthesia, Inhalation* Animals Arginine / analogs & derivatives*, pharmacology Brain / blood supply* Cerebrovascular Circulation / physiology* Consciousness / physiology Isoflurane* Male NG-Nitroarginine Methyl Ester Nitric Oxide Synthase Rats Vascular Resistance / physiology* |
| Chemical | |
Reg. No./Substance:
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26675-46-7/Isoflurane; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases |
| Comments/Corrections | |
Comment In:
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Anesth Analg. 1993 Nov;77(5):877-9
[PMID:
8105725
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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