Document Detail

Effects of nitric oxide inhibition on basal forearm blood flow in patients with nonischemic chronic heart failure.
MedLine Citation:
PMID:  10328184     Owner:  NLM     Status:  MEDLINE    
Increased peripheral vascular tone in patients with chronic heart failure (CHF) is an important factor which contributes to increased cardiac afterload and reduced exercise capacity, and consequent further deterioration in CHF. The role of endogenous nitric oxide (NO) in the regulation of basal vascular tone in CHF is controversial. This study has investigated (1) whether basal NO bioavailability is reduced in the peripheral vasculature of patients with nonischemic CHF in the absence of confounding factors influencing endothelial function, and (2) if a difference is found, what clinical characteristics are related to the decreased NO-dependent vasodilation. Basal forearm blood flow (FBF) of 12 patients with CHF and 14 healthy volunteers was measured before and after administration of N(G)-monomethyl-L-arginine (L-NMMA) by venous occlusion plethysmography. After L-NMMA administration, basal FBF in both healthy subjects and patients with CHF decreased significantly, with the decrease in CHF patients being less than that in healthy volunteers (-0.7+/-0.2 vs -1.5+/-0.2 ml/min per 100 ml tissue, P < 0.01). When both groups were considered together, basal FBF was closely related to the decrease in FBF after L-NMMA administration (r = -0.83. P < 0.001). When CHF patients were divided into two groups according to NYHA class, the L-NMMA-induced decrease in FBF in moderate CHF (NYHA III; n = 7) was significantly less than that in mild CHF (NYHA II; n = 5) (-0.36+/-0.13 vs -1.16+/-0.72 ml/min per 100 ml tissue, P < 0.05). In conclusion, basal bioavailability of NO in the peripheral vascular bed in nonischemic CHF is impaired, with an increase in basal vascular tone and with progression of this disorder. This suggests that impaired basal NO bioactivity may make an important contribution to the elevated peripheral vascular tone and expression of symptoms seen in CHF.
H Yoshida; M Nakamura; T Akatsu; N Arakawa; K Hiramori
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  13     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1998  
Date Detail:
Created Date:  1999-07-12     Completed Date:  1999-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  IM    
Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
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MeSH Terms
Blood Flow Velocity
Enzyme Inhibitors / pharmacology
Forearm / blood supply*
Heart Failure / blood,  drug therapy,  physiopathology*
Infusions, Intra-Arterial
Middle Aged
Nitric Oxide / antagonists & inhibitors*,  biosynthesis
Nitric Oxide Synthase / antagonists & inhibitors*
Reproducibility of Results
Vascular Resistance
omega-N-Methylarginine / pharmacology
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; EC Oxide Synthase

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