| Effects of nitric oxide in mucociliary transport. | |
| | |
MedLine Citation:
|
PMID: 20209289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: to assess NO participation and the enzymatic pathways in the production of NO and mucociliary transport, using constructive and inductive NO synthetase inhibitors, L-NAME and aminoguanidine, respectively. MATERIALS AND METHODS: frog palates were prepared and immersed in ringer (control), L-NAME or aminoguanidine solutions. The palates were immersed in these solutions for four periods of 15 minutes. Mucociliary transport measures were carried out before and after each exposure. RESULTS: control palates maintained stable their transportation speed. L-NAME increased, while aminoguanidine reduced mucous transportation velocity. CONCLUSION: unspecific cNOS block with L-NAME and relatively specific iNOS block with aminoguanidine results leads us to propose that depending on the pathway, the NO can increase or reduce mucociliary transport in frog palates. |
| | |
Authors:
|
Eleonora Elisia Abra Blanco; Marli Cardoso Martins Pinge; Otavio André Andrade Neto; Nathália Gardin Pessoa |
Related Documents
:
|
789069 - Toxicity and health effects of selected organotin compounds: a review. 3570619 - Nitric oxide yields of contemporary uk, us and french cigarettes. 11536519 - An efficient lightning energy source on the early earth. 17295449 - In situ studies of fuel oxidation in solid oxide fuel cells. 15891329 - Lack of alteration of endogenous nitric oxide pathway during prolonged nitric oxide inh... 7705309 - Generation of oxygen radicals and mechanisms of injury prevention. 21509839 - Direct arylation of heteroaromatic compounds with congested, functionalised aryl bromid... 20685279 - A concise synthesis of beta-sitosterol and other phytosterols. 19694429 - Reductive and brominative termination of alkenol cyclization in aerobic cobalt-catalyze... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Brazilian journal of otorhinolaryngology Volume: 75 ISSN: 1808-8686 ISO Abbreviation: Braz J Otorhinolaryngol Publication Date: 2009 Nov-Dec |
Date Detail:
|
Created Date: 2010-03-08 Completed Date: 2010-06-22 Revised Date: 2011-10-04 |
Medline Journal Info:
|
Nlm Unique ID: 101207337 Medline TA: Braz J Otorhinolaryngol Country: Brazil |
Other Details:
|
Languages: eng Pagination: 866-71 Citation Subset: IM |
Affiliation:
|
Londrina Federal University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anura Enzyme Inhibitors / pharmacology Guanidines / pharmacology Mucociliary Clearance / drug effects*, physiology NG-Nitroarginine Methyl Ester / pharmacology Nasal Mucosa / enzymology* Nitric Oxide / antagonists & inhibitors, physiology* Nitric Oxide Synthase Type II / antagonists & inhibitors* Nitric Oxide Synthase Type III / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 0/Guanidines; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 79-17-4/pimagedine; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical outcome of patients with epistaxis treated with nasal packing after hospital discharge.
Next Document: Standardizing selection criteria in nasal medication studies.