| Effects of the nitric oxide donor nitroprusside on no-reflow phenomenon during coronary interventions for acute myocardial infarction. | |
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MedLine Citation:
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PMID: 15904643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We tested the effects of the nitric oxide donor nitroprusside as treatment for no reflow in 23 consecutive patients who underwent coronary angioplasty for acute myocardial infarction. No reflow was defined as a decrease of >/=1 Thrombolysis In Myocardial Infarction (TIMI) trial flow grade occurring after successful initial coronary recanalization. Nitroprusside induced a significant improvement in coronary flow, with an increase in TIMI flow grade from 1.5 +/- 0.8 to 2.9 +/- 0.3 (p <0.0001) and in TIMI frame count from 46 +/- 25 to 16 +/- 5 (p <0.0001). There were no significant adverse effects apart from transient hypotension. Intracoronary nitroprusside should be considered as a treatment of no reflow occurring in acute myocardial infarction. |
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Authors:
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Vincenzo Pasceri; Christian Pristipino; Francesco Pelliccia; Antonino Granatelli; Giulio Speciale; Adriana Roncella; Bruno Pironi; Michele Capasso; Giuseppe Richichi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 95 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-20 Completed Date: 2005-07-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1358-61 Citation Subset: AIM; IM |
Affiliation:
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Interventional Cardiology Unit, San Filippo Neri Hospital, Rome, Italy. vpasceri@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Coronary Circulation / drug effects* Female Humans Male Middle Aged Myocardial Infarction / physiopathology*, therapy* Nitric Oxide Donors / therapeutic use* Nitroprusside / therapeutic use* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Nitric Oxide Donors; 15078-28-1/Nitroprusside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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