| Effects of nitric oxide donor on hepatic arterial buffer response in anesthetized pigs. | |
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MedLine Citation:
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PMID: 20690842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of systemic administration of exogenous nitric oxide (NO) donor on hepatic arterial buffer response (HABR) have not yet been studied in an anesthetized model. In this study, 28 anesthetized pigs received administration of sodium nitroprusside (SNP) or nitroglycerin (NTG) as exogenous NO donors. Pressure-flow (P-Q) relationships in the hepatic artery defined the pressure at zero flow (P(Qha = 0)) and flow-dependent resistance (R). The magnitude of HABR was evaluated by comparing the change in hepatic arterial blood flow (DeltaQha) divided by the change in portal venous blood flow (DeltaQpv), using the index of change in blood flow (DeltaQha/DeltaQpv). Mean arterial pressure decreased from baseline (95.6 +/- 3.8 mmHg) to SNP condition (68.3 +/- 1.9 mmHg) and decreased from baseline (92.7 +/- 4.4 mmHg) to NTG condition (66.2 +/- 1.7 mmHg). Mean index of change in blood flow (DeltaQha/DeltaQpv) was also significantly increased from baseline (0.19 +/- 0.12) to SNP condition (0.28 +/- 0.17; p = .009) and from baseline (0.18 +/- 0.17) to NTG (0.28 +/- 0.20; p < .05). In conclusion, systemic administration of SNP and NTG increases HABR with reduced hepatic arterial tone under decreased mean arterial pressure, presumably via exogenous NO enhancing another regulatory system and reducing the pressure gradient for sinusoidal washout. |
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Authors:
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Takao Ayuse; Kentaro Mishima; Kumiko Oi; Hiroyuki Ureshino; Koji Sumikawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of investigative surgery : the official journal of the Academy of Surgical Research Volume: 23 ISSN: 1521-0553 ISO Abbreviation: J Invest Surg Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809255 Medline TA: J Invest Surg Country: England |
Other Details:
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Languages: eng Pagination: 183-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, Nagasaki University, Nagasaki, Japan. ayuse@nagasaki-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Intravenous
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pharmacology Animals Blood Flow Velocity / drug effects, physiology Blood Pressure / drug effects, physiology Hepatic Artery / drug effects, physiology* Male Models, Animal Models, Biological Nitric Oxide Donors / pharmacology* Nitroglycerin / pharmacology* Nitroprusside / pharmacology* Regional Blood Flow / drug effects*, physiology Swine |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Nitric Oxide Donors; 15078-28-1/Nitroprusside; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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