| Effects of nifedipine on systemic and pulmonary vascular impedance in subjects undergoing cardiac catheterization. | |
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MedLine Citation:
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PMID: 17044663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nifedipine 10 mg, administered sublingually to 12 patients following diagnostic cardiac catheterization, caused reduction in systemic resistance, and change of impedance together with alteration in contour of the ascending aortic and left ventricular pressure waves. The substantial reduction in ascending aortic and left ventricular systolic pressure with nifedipine occurred despite an increase in stroke volume and cardiac output, and was associated with similar reductions in mean pressure and indices of wave reflection. In the same patients, there were no significant changes in pulmonary vascular resistance or impedance, nor in pulmonary artery or right ventricular pressure pulse contour. For the systemic circulation, as with nitroglycerin and nitroprusside, reduction in wave reflection appears to be an important factor in the drug's action and for its beneficial effects on cardiac load in the treatment of angina pectoris, systemic hypertension and left ventricular failure. Thus the observed effects of nifedipine were attributed to vasodilatation of the systemic arteries and arterioles. |
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Authors:
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Toshitaka Noda; Toshio Yaginuma; Michael F O'Rourke; Saichi Hosoda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 29 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2006-11-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 505-13 Citation Subset: IM |
Affiliation:
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Noda Clinic, Yamaguchi, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Sublingual Adult Algorithms Calcium Channel Blockers / pharmacology* Cardiac Output / drug effects Coronary Circulation / physiology Data Interpretation, Statistical Heart Catheterization* Hemodynamics / physiology Humans Male Middle Aged Myocardial Ischemia / physiopathology Nifedipine / pharmacology* Pulmonary Circulation / drug effects* Vascular Resistance / drug effects* Vasodilation / drug effects Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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