Document Detail

Effects of nifedipine on systemic and pulmonary vascular impedance in subjects undergoing cardiac catheterization.
MedLine Citation:
PMID:  17044663     Owner:  NLM     Status:  MEDLINE    
Nifedipine 10 mg, administered sublingually to 12 patients following diagnostic cardiac catheterization, caused reduction in systemic resistance, and change of impedance together with alteration in contour of the ascending aortic and left ventricular pressure waves. The substantial reduction in ascending aortic and left ventricular systolic pressure with nifedipine occurred despite an increase in stroke volume and cardiac output, and was associated with similar reductions in mean pressure and indices of wave reflection. In the same patients, there were no significant changes in pulmonary vascular resistance or impedance, nor in pulmonary artery or right ventricular pressure pulse contour. For the systemic circulation, as with nitroglycerin and nitroprusside, reduction in wave reflection appears to be an important factor in the drug's action and for its beneficial effects on cardiac load in the treatment of angina pectoris, systemic hypertension and left ventricular failure. Thus the observed effects of nifedipine were attributed to vasodilatation of the systemic arteries and arterioles.
Toshitaka Noda; Toshio Yaginuma; Michael F O'Rourke; Saichi Hosoda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  29     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-11-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  505-13     Citation Subset:  IM    
Noda Clinic, Yamaguchi, Japan.
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MeSH Terms
Administration, Sublingual
Calcium Channel Blockers / pharmacology*
Cardiac Output / drug effects
Coronary Circulation / physiology
Data Interpretation, Statistical
Heart Catheterization*
Hemodynamics / physiology
Middle Aged
Myocardial Ischemia / physiopathology
Nifedipine / pharmacology*
Pulmonary Circulation / drug effects*
Vascular Resistance / drug effects*
Vasodilation / drug effects
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine

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