| Effects of nifedipine on coronary reactive and exercise induced hyperaemia. | |
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MedLine Citation:
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PMID: 3440269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of nifedipine on coronary vasodilation were studied during reactive hyperaemia after a transient coronary occlusion and during active hyperaemia associated with graded treadmill exercise. Studies were performed in 10 chronically instrumented dogs in which left circumflex coronary artery flow was measured with an electromagnetic flowmeter and myocardial oxygen extraction was determined from indwelling aortic and coronary sinus catheters. Thirty minutes after administration of nifedipine (10 micrograms.kg-1 iv), when coronary blood flow, arterial pressure, and heart rate had returned to control values, the vasodilatation following a 10 s coronary occlusion was significantly blunted, so that reactive hyperaemia blood flow debt repayment (mean(SEM)) was reduced from 387(39)% during control conditions to 270(33)% after nifedipine (p less than 0.05). In contrast, nifedipine did not alter the coronary vasodilatation that occurred in response to graded treadmill exercise so that the increase in coronary blood flow during exercise was not different from the control response. Thus, although nifedipine blunted ischaemic coronary vasodilatation during reactive hyperaemia, it did not alter coronary vasodilatation during active hyperaemia resulting from physiological increases of myocardial oxygen consumption. |
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Authors:
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R J Bache; D Quanbeck; D C Homans; X Z Dai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cardiovascular research Volume: 21 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-04-18 Completed Date: 1988-04-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 766-71 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Minnesota Medical School, Minneapolis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / complications Coronary Circulation / drug effects* Coronary Disease / complications Dogs Hemodynamics / drug effects Hyperemia / etiology, physiopathology* Nifedipine / pharmacology* Oxygen Consumption / drug effects Physical Exertion* Vasodilation / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL20598/HL/NHLBI NIH HHS; HL34701/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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