| Effects of nifedipine GITS 20 mg or enalapril 20 mg on blood pressure and inflammatory markers in patients with mild-moderate hypertension. | |
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MedLine Citation:
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PMID: 16060412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Calcium antagonists, angiotensin-converting enzyme (ACE) inhibitors and other drug classes either alone or in combination have been recommended for the treatment of hypertension. Nifedipine gastrointestinal therapeutic system (GITS) 20 mg is a new low-dose formulation with an improved tolerability. The aim of the present study was to compare the effects of nifedipine GITS 20 mg and enalapril 20 mg on blood pressure and circulating adhesion molecules in hypertensive patients. METHODS: This randomized, double-blind, multicentre trial compared the blood pressure lowering effects of a 12-week treatment of nifedipine GITS 20 mg vs enalapril 20 mg in 264 patients with mild-to-moderate hypertension. RESULTS: Nifedipine GITS 20 mg induced a reduction of clinic blood pressure, which was similar to that observed with enalapril 20 mg. Nifedipine GITS and enalapril lowered mean sitting diastolic blood pressure by 11.8 and 12.4 mmHg, respectively, while systolic blood pressure was reduced by 15.3 and 16.3 mmHg, respectively. Ambulatory blood pressure monitoring-derived blood pressure data showed similar results in both groups without any statistically significant differences between treatments. Both enalapril and nifedipine tended to reduce ICAM-1 and E-selectin, while only nifedipine reduced von Willebrand factor. Both treatments were well tolerated. CONCLUSIONS: Our findings demonstrate a similar antihypertensive effectiveness of a low dose (20 mg) of nifedipine GITS in comparison with a standard dose of enalapril (20 mg). Given its clinical efficacy and good tolerability, low-dose nifedipine GITS may be considered a valuable treatment option for hypertensive patients. |
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Authors:
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Enrico Agabiti Rosei; Patrizia Morelli; Damiano Rizzoni |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood pressure. Supplement Volume: 1 ISSN: 0803-8023 ISO Abbreviation: Blood Press Suppl Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-08-02 Completed Date: 2005-09-15 Revised Date: 2008-02-26 |
Medline Journal Info:
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Nlm Unique ID: 9300787 Medline TA: Blood Press Suppl Country: Norway |
Other Details:
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Languages: eng Pagination: 14-22 Citation Subset: IM |
Affiliation:
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Chair of Internal Medicine, Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy. agabiti@med.unibs.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiotensin-Converting Enzyme Inhibitors / pharmacology Blood Pressure / drug effects* Blood Pressure Determination Blood Pressure Monitoring, Ambulatory E-Selectin / biosynthesis Enalapril / pharmacology* Female Humans Hypertension / drug therapy* Inflammation Intercellular Adhesion Molecule-1 / biosynthesis Male Middle Aged Nifedipine / administration & dosage*, pharmacology* Treatment Outcome Vasodilator Agents / pharmacology von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/E-Selectin; 0/Vasodilator Agents; 0/von Willebrand Factor; 126547-89-5/Intercellular Adhesion Molecule-1; 21829-25-4/Nifedipine; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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