Document Detail

Effects of nicotine and inhalation of cigarette smoke on total body oxygen consumption in dogs.
MedLine Citation:
PMID:  1129594     Owner:  NLM     Status:  MEDLINE    
The effects on total body oxygen consumption of nicotine infused intravenously and of simulated cigarette smoking were studied in intact anesthetized dogs. Nicotine infusion and simulated cigarette smoking raised total body oxygen consumption by 9 plus or minus 2% (mean plus or minus S.E.M.; P smaller than 0.02) and 6 plus or minus 2% (P smaller than 0.05), respectively, and arterial concentration of free fatty acids (FFA) by 29 plus or minus 9% (P smaller than 0.05) and 12 plus or minus 3% (P smaller than 0.01). When nicotine infusion and simulated cigarette smoking were repeated during inhibition of lipolysis with beta-pyridylcarbinol, no rise in total body oxygen consumption occurred, although the mean aortic blood pressure and heart rate remained elevated to levels similar to those during intact lipolysis. It is concluded that the rise in total body oxygen consumption induced by intravenously infused nicotine or simulated cigarette smoking was probably mediated through increased mobilization and consumption of FFA.
A Ilebekk; N E Miller; O D Mjös
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  35     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-07-24     Completed Date:  1975-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Fatty Acids, Nonesterified / blood,  metabolism*
Heart Rate / drug effects
Infusions, Parenteral
Lipid Metabolism
Nicotine / pharmacology*
Nicotinyl Alcohol / pharmacology
Oxygen Consumption / drug effects*
Palmitic Acids / metabolism
Stimulation, Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Palmitic Acids; 0/Smoke; 100-55-0/Nicotinyl Alcohol; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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