| Effects of nicotine and inhalation of cigarette smoke on total body oxygen consumption in dogs. | |
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MedLine Citation:
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PMID: 1129594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects on total body oxygen consumption of nicotine infused intravenously and of simulated cigarette smoking were studied in intact anesthetized dogs. Nicotine infusion and simulated cigarette smoking raised total body oxygen consumption by 9 plus or minus 2% (mean plus or minus S.E.M.; P smaller than 0.02) and 6 plus or minus 2% (P smaller than 0.05), respectively, and arterial concentration of free fatty acids (FFA) by 29 plus or minus 9% (P smaller than 0.05) and 12 plus or minus 3% (P smaller than 0.01). When nicotine infusion and simulated cigarette smoking were repeated during inhibition of lipolysis with beta-pyridylcarbinol, no rise in total body oxygen consumption occurred, although the mean aortic blood pressure and heart rate remained elevated to levels similar to those during intact lipolysis. It is concluded that the rise in total body oxygen consumption induced by intravenously infused nicotine or simulated cigarette smoking was probably mediated through increased mobilization and consumption of FFA. |
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Authors:
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A Ilebekk; N E Miller; O D Mjös |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 35 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-07-24 Completed Date: 1975-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: NORWAY |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Dogs Fatty Acids, Nonesterified / blood, metabolism* Female Heart Rate / drug effects Infusions, Parenteral Lipid Metabolism Male Nicotine / pharmacology* Nicotinyl Alcohol / pharmacology Oxygen Consumption / drug effects* Palmitic Acids / metabolism Smoke* Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Palmitic Acids; 0/Smoke; 100-55-0/Nicotinyl Alcohol; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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